Cargando…
Epidemic spread of ST1-MRSA-IVa in a neonatal intensive care unit, Italy
BACKGROUND: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has recently emerged as an important pathogen in neonatal intensive care units (NICUs). The purposes of this study were to characterize methicillin-resistant isolates from an outbreak in a NICU, to examine the gen...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407518/ https://www.ncbi.nlm.nih.gov/pubmed/22682025 http://dx.doi.org/10.1186/1471-2431-12-64 |
_version_ | 1782239345948753920 |
---|---|
author | Giuffrè, Mario Cipolla, Domenico Bonura, Celestino Geraci, Daniela Maria Aleo, Aurora Di Noto, Stefania Nociforo, Federica Corsello, Giovanni Mammina, Caterina |
author_facet | Giuffrè, Mario Cipolla, Domenico Bonura, Celestino Geraci, Daniela Maria Aleo, Aurora Di Noto, Stefania Nociforo, Federica Corsello, Giovanni Mammina, Caterina |
author_sort | Giuffrè, Mario |
collection | PubMed |
description | BACKGROUND: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has recently emerged as an important pathogen in neonatal intensive care units (NICUs). The purposes of this study were to characterize methicillin-resistant isolates from an outbreak in a NICU, to examine the genetic traits and clonality of CA-MRSA, and to review the characteristics and outcomes of the neonatal cases and investigate the routes of entry and transmission of the MRSA outbreak strain in the NICU under study. METHODS: The study NICU practiced an active surveillance program for multidrug-resistant organisms, including weekly cultures for detection of MRSA from nasal swabs among all the admitted neonates. All first isolates from surveillance cultures and all clinical isolates were submitted for susceptibility testing and genotyping. Data from each infant’s medical records were prospectively included in a database, and the clinical features and outcomes of the colonized/infected infants were assessed. RESULTS: A total of 14 infants were colonized or infected by a strain of ST1-MRSA-IVa between April and August 2011. The CA-MRSA strain appeared to have been introduced to the NICU by an infected infant transferred from another hospital. The outbreak was successfully contained by multifaceted infection control interventions. CONCLUSIONS: The results of this study confirm that NICU is a healthcare setting with a critical permeability to CA-MRSA. Active surveillance including molecular typing can help to detect and monitor the spread of antimicrobial drug-resistant organisms, and thus trigger timely control interventions. |
format | Online Article Text |
id | pubmed-3407518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34075182012-07-29 Epidemic spread of ST1-MRSA-IVa in a neonatal intensive care unit, Italy Giuffrè, Mario Cipolla, Domenico Bonura, Celestino Geraci, Daniela Maria Aleo, Aurora Di Noto, Stefania Nociforo, Federica Corsello, Giovanni Mammina, Caterina BMC Pediatr Research Article BACKGROUND: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has recently emerged as an important pathogen in neonatal intensive care units (NICUs). The purposes of this study were to characterize methicillin-resistant isolates from an outbreak in a NICU, to examine the genetic traits and clonality of CA-MRSA, and to review the characteristics and outcomes of the neonatal cases and investigate the routes of entry and transmission of the MRSA outbreak strain in the NICU under study. METHODS: The study NICU practiced an active surveillance program for multidrug-resistant organisms, including weekly cultures for detection of MRSA from nasal swabs among all the admitted neonates. All first isolates from surveillance cultures and all clinical isolates were submitted for susceptibility testing and genotyping. Data from each infant’s medical records were prospectively included in a database, and the clinical features and outcomes of the colonized/infected infants were assessed. RESULTS: A total of 14 infants were colonized or infected by a strain of ST1-MRSA-IVa between April and August 2011. The CA-MRSA strain appeared to have been introduced to the NICU by an infected infant transferred from another hospital. The outbreak was successfully contained by multifaceted infection control interventions. CONCLUSIONS: The results of this study confirm that NICU is a healthcare setting with a critical permeability to CA-MRSA. Active surveillance including molecular typing can help to detect and monitor the spread of antimicrobial drug-resistant organisms, and thus trigger timely control interventions. BioMed Central 2012-06-08 /pmc/articles/PMC3407518/ /pubmed/22682025 http://dx.doi.org/10.1186/1471-2431-12-64 Text en Copyright ©2012 Giuffrè et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Giuffrè, Mario Cipolla, Domenico Bonura, Celestino Geraci, Daniela Maria Aleo, Aurora Di Noto, Stefania Nociforo, Federica Corsello, Giovanni Mammina, Caterina Epidemic spread of ST1-MRSA-IVa in a neonatal intensive care unit, Italy |
title | Epidemic spread of ST1-MRSA-IVa in a neonatal intensive care unit, Italy |
title_full | Epidemic spread of ST1-MRSA-IVa in a neonatal intensive care unit, Italy |
title_fullStr | Epidemic spread of ST1-MRSA-IVa in a neonatal intensive care unit, Italy |
title_full_unstemmed | Epidemic spread of ST1-MRSA-IVa in a neonatal intensive care unit, Italy |
title_short | Epidemic spread of ST1-MRSA-IVa in a neonatal intensive care unit, Italy |
title_sort | epidemic spread of st1-mrsa-iva in a neonatal intensive care unit, italy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407518/ https://www.ncbi.nlm.nih.gov/pubmed/22682025 http://dx.doi.org/10.1186/1471-2431-12-64 |
work_keys_str_mv | AT giuffremario epidemicspreadofst1mrsaivainaneonatalintensivecareunititaly AT cipolladomenico epidemicspreadofst1mrsaivainaneonatalintensivecareunititaly AT bonuracelestino epidemicspreadofst1mrsaivainaneonatalintensivecareunititaly AT geracidanielamaria epidemicspreadofst1mrsaivainaneonatalintensivecareunititaly AT aleoaurora epidemicspreadofst1mrsaivainaneonatalintensivecareunititaly AT dinotostefania epidemicspreadofst1mrsaivainaneonatalintensivecareunititaly AT nociforofederica epidemicspreadofst1mrsaivainaneonatalintensivecareunititaly AT corsellogiovanni epidemicspreadofst1mrsaivainaneonatalintensivecareunititaly AT mamminacaterina epidemicspreadofst1mrsaivainaneonatalintensivecareunititaly |