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Pituitary tumorous hyperplasia due to primary hypothyroidism

BACKGROUND: To study the diagnostic and therapeutic features of pituitary tumorous hyperplasia due to primary hypothyroidism. METHODS: Fifteen patients with pituitary tumorous hyperplasia were studied in clinical manifestation, pathologic, endocrinological, radiographic and therapeutic features retr...

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Detalles Bibliográficos
Autores principales: Han, Lin, Wang, Junwen, Shu, Kai, Lei, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407554/
https://www.ncbi.nlm.nih.gov/pubmed/22527578
http://dx.doi.org/10.1007/s00701-012-1342-0
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author Han, Lin
Wang, Junwen
Shu, Kai
Lei, Ting
author_facet Han, Lin
Wang, Junwen
Shu, Kai
Lei, Ting
author_sort Han, Lin
collection PubMed
description BACKGROUND: To study the diagnostic and therapeutic features of pituitary tumorous hyperplasia due to primary hypothyroidism. METHODS: Fifteen patients with pituitary tumorous hyperplasia were studied in clinical manifestation, pathologic, endocrinological, radiographic and therapeutic features retrospectively. RESULTS: All of these patients suffered from primary hypothyroidism. Magnetic resonance imaging (MRI) scanning found that there were masses in the sellar region with equal T1 and little longer T2 signal, and which could be obviously enhanced by gadolinium EDTA injection. Diameters of these masses were between 1.1 and 2.5 cm. Thyroxine substitution therapy was ordered. Four months later, MRI scanning found that the masses disappeared and only normal pituitary gland left. Plasma thyroxine, thyroid-stimulating hormone (TSH), and prolactin (PRL) levels dropped to their normal ranges. CONCLUSIONS: Thyroxine substitution therapy was the first choice of pituitary tumorous hyperplasia due to primary hypothyroidism. If they are followed by TSH adenoma, or the optic chiasma was pressed by the enlarged pituitary, transsphenoidal microsurgery could be applied.
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spelling pubmed-34075542012-08-02 Pituitary tumorous hyperplasia due to primary hypothyroidism Han, Lin Wang, Junwen Shu, Kai Lei, Ting Acta Neurochir (Wien) Clinical Article BACKGROUND: To study the diagnostic and therapeutic features of pituitary tumorous hyperplasia due to primary hypothyroidism. METHODS: Fifteen patients with pituitary tumorous hyperplasia were studied in clinical manifestation, pathologic, endocrinological, radiographic and therapeutic features retrospectively. RESULTS: All of these patients suffered from primary hypothyroidism. Magnetic resonance imaging (MRI) scanning found that there were masses in the sellar region with equal T1 and little longer T2 signal, and which could be obviously enhanced by gadolinium EDTA injection. Diameters of these masses were between 1.1 and 2.5 cm. Thyroxine substitution therapy was ordered. Four months later, MRI scanning found that the masses disappeared and only normal pituitary gland left. Plasma thyroxine, thyroid-stimulating hormone (TSH), and prolactin (PRL) levels dropped to their normal ranges. CONCLUSIONS: Thyroxine substitution therapy was the first choice of pituitary tumorous hyperplasia due to primary hypothyroidism. If they are followed by TSH adenoma, or the optic chiasma was pressed by the enlarged pituitary, transsphenoidal microsurgery could be applied. Springer Vienna 2012-04-17 2012 /pmc/articles/PMC3407554/ /pubmed/22527578 http://dx.doi.org/10.1007/s00701-012-1342-0 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Clinical Article
Han, Lin
Wang, Junwen
Shu, Kai
Lei, Ting
Pituitary tumorous hyperplasia due to primary hypothyroidism
title Pituitary tumorous hyperplasia due to primary hypothyroidism
title_full Pituitary tumorous hyperplasia due to primary hypothyroidism
title_fullStr Pituitary tumorous hyperplasia due to primary hypothyroidism
title_full_unstemmed Pituitary tumorous hyperplasia due to primary hypothyroidism
title_short Pituitary tumorous hyperplasia due to primary hypothyroidism
title_sort pituitary tumorous hyperplasia due to primary hypothyroidism
topic Clinical Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407554/
https://www.ncbi.nlm.nih.gov/pubmed/22527578
http://dx.doi.org/10.1007/s00701-012-1342-0
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AT leiting pituitarytumoroushyperplasiaduetoprimaryhypothyroidism