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Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish
Over the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and improvements in our capacity to identify, isolate, and culture...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407620/ https://www.ncbi.nlm.nih.gov/pubmed/22851971 http://dx.doi.org/10.1155/2012/358518 |
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author | Forrester, A. Michael Berman, Jason N. Payne, Elspeth M. |
author_facet | Forrester, A. Michael Berman, Jason N. Payne, Elspeth M. |
author_sort | Forrester, A. Michael |
collection | PubMed |
description | Over the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and improvements in our capacity to identify, isolate, and culture such haematopoietic cells continue to enhance our ability to use this simple organism to address disease biology. Coupled with the strengths of the zebrafish embryo to dissect developmental myelopoiesis and the continually expanding repertoire of models of myeloid malignancies, this versatile organism has established its niche as a valuable tool to address key questions in the field of myelopoiesis and myeloid leukaemogenesis. In this paper, we address the recent advances and future directions in the field of myelopoiesis and leukaemogenesis using the zebrafish system. |
format | Online Article Text |
id | pubmed-3407620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34076202012-07-31 Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish Forrester, A. Michael Berman, Jason N. Payne, Elspeth M. Adv Hematol Review Article Over the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and improvements in our capacity to identify, isolate, and culture such haematopoietic cells continue to enhance our ability to use this simple organism to address disease biology. Coupled with the strengths of the zebrafish embryo to dissect developmental myelopoiesis and the continually expanding repertoire of models of myeloid malignancies, this versatile organism has established its niche as a valuable tool to address key questions in the field of myelopoiesis and myeloid leukaemogenesis. In this paper, we address the recent advances and future directions in the field of myelopoiesis and leukaemogenesis using the zebrafish system. Hindawi Publishing Corporation 2012 2012-07-19 /pmc/articles/PMC3407620/ /pubmed/22851971 http://dx.doi.org/10.1155/2012/358518 Text en Copyright © 2012 A. Michael Forrester et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Forrester, A. Michael Berman, Jason N. Payne, Elspeth M. Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish |
title | Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish |
title_full | Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish |
title_fullStr | Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish |
title_full_unstemmed | Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish |
title_short | Myelopoiesis and Myeloid Leukaemogenesis in the Zebrafish |
title_sort | myelopoiesis and myeloid leukaemogenesis in the zebrafish |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407620/ https://www.ncbi.nlm.nih.gov/pubmed/22851971 http://dx.doi.org/10.1155/2012/358518 |
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