MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis

MicroRNAs (miRs) are post-transcriptional inhibitory regulators of gene expression acting by direct binding to complementary messenger RNA (mRNA) transcripts. Recent studies have demonstrated that miRs are crucial determinants of endothelial cell behavior and angiogenesis. We have provided evidence...

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Detalles Bibliográficos
Autores principales: Caporali, Andrea, Emanueli, Costanza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Publishing 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407871/
https://www.ncbi.nlm.nih.gov/pubmed/22814423
http://dx.doi.org/10.1016/j.tcm.2012.05.003
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author Caporali, Andrea
Emanueli, Costanza
author_facet Caporali, Andrea
Emanueli, Costanza
author_sort Caporali, Andrea
collection PubMed
description MicroRNAs (miRs) are post-transcriptional inhibitory regulators of gene expression acting by direct binding to complementary messenger RNA (mRNA) transcripts. Recent studies have demonstrated that miRs are crucial determinants of endothelial cell behavior and angiogenesis. We have provided evidence of the prominent role of miR-503 in impairment of postischemic reparative angiogenesis in the setting of diabetes. Because miR-503 belongs to the miR-16 extended family of miRs, in this review, we describe the cardiovascular functions of miR-503 and other members of the miR-16 family and their impact on angiogenesis.
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spelling pubmed-34078712012-08-06 MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis Caporali, Andrea Emanueli, Costanza Trends Cardiovasc Med Review Article MicroRNAs (miRs) are post-transcriptional inhibitory regulators of gene expression acting by direct binding to complementary messenger RNA (mRNA) transcripts. Recent studies have demonstrated that miRs are crucial determinants of endothelial cell behavior and angiogenesis. We have provided evidence of the prominent role of miR-503 in impairment of postischemic reparative angiogenesis in the setting of diabetes. Because miR-503 belongs to the miR-16 extended family of miRs, in this review, we describe the cardiovascular functions of miR-503 and other members of the miR-16 family and their impact on angiogenesis. Elsevier Science Publishing 2011-08 /pmc/articles/PMC3407871/ /pubmed/22814423 http://dx.doi.org/10.1016/j.tcm.2012.05.003 Text en © 2011 Elsevier Inc. https://creativecommons.org/licenses/by/4.0/ Open Access under CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) license
spellingShingle Review Article
Caporali, Andrea
Emanueli, Costanza
MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis
title MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis
title_full MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis
title_fullStr MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis
title_full_unstemmed MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis
title_short MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis
title_sort microrna-503 and the extended microrna-16 family in angiogenesis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407871/
https://www.ncbi.nlm.nih.gov/pubmed/22814423
http://dx.doi.org/10.1016/j.tcm.2012.05.003
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