Cyclisation Increases the Stability of the Sea Anemone Peptide APETx2 but Decreases Its Activity at Acid-Sensing Ion Channel 3

APETx2 is a peptide isolated from the sea anemone Anthopleura elegantissima. It is the most potent and selective inhibitor of acid-sensing ion channel 3 (ASIC3) and it is currently in preclinical studies as a novel analgesic for the treatment of chronic inflammatory pain. As a peptide it faces many...

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Detalles Bibliográficos
Autores principales: Jensen, Jonas E., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F., Rash, Lachlan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407927/
https://www.ncbi.nlm.nih.gov/pubmed/22851922
http://dx.doi.org/10.3390/md10071511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407927/
https://www.ncbi.nlm.nih.gov/pubmed/22851922
http://dx.doi.org/10.3390/md10071511

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