4-Methylenesterols from a Sponge Theonella swinhoei

Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the bas...

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Autores principales: Guo, Jheng-Kun, Chiang, Ching-Ying, Lu, Mei-Chin, Chang, Wen-Been, Su, Jui-Hsin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407929/
https://www.ncbi.nlm.nih.gov/pubmed/22851924
http://dx.doi.org/10.3390/md10071536
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author Guo, Jheng-Kun
Chiang, Ching-Ying
Lu, Mei-Chin
Chang, Wen-Been
Su, Jui-Hsin
author_facet Guo, Jheng-Kun
Chiang, Ching-Ying
Lu, Mei-Chin
Chang, Wen-Been
Su, Jui-Hsin
author_sort Guo, Jheng-Kun
collection PubMed
description Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines.
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spelling pubmed-34079292012-07-31 4-Methylenesterols from a Sponge Theonella swinhoei Guo, Jheng-Kun Chiang, Ching-Ying Lu, Mei-Chin Chang, Wen-Been Su, Jui-Hsin Mar Drugs Article Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines. MDPI 2012-07-19 /pmc/articles/PMC3407929/ /pubmed/22851924 http://dx.doi.org/10.3390/md10071536 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Guo, Jheng-Kun
Chiang, Ching-Ying
Lu, Mei-Chin
Chang, Wen-Been
Su, Jui-Hsin
4-Methylenesterols from a Sponge Theonella swinhoei
title 4-Methylenesterols from a Sponge Theonella swinhoei
title_full 4-Methylenesterols from a Sponge Theonella swinhoei
title_fullStr 4-Methylenesterols from a Sponge Theonella swinhoei
title_full_unstemmed 4-Methylenesterols from a Sponge Theonella swinhoei
title_short 4-Methylenesterols from a Sponge Theonella swinhoei
title_sort 4-methylenesterols from a sponge theonella swinhoei
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407929/
https://www.ncbi.nlm.nih.gov/pubmed/22851924
http://dx.doi.org/10.3390/md10071536
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AT changwenbeen 4methylenesterolsfromaspongetheonellaswinhoei
AT sujuihsin 4methylenesterolsfromaspongetheonellaswinhoei

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