Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes

Seven new sesquiterpenoids, lochmolins A–G (1–7), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1–4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protei...

Descripción completa

Detalles Bibliográficos
Autores principales: Tseng, Yen-Ju, Shen, Kuo-Ping, Lin, Hui-Li, Huang, Chiung-Yao, Dai, Chang-Feng, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407932/
https://www.ncbi.nlm.nih.gov/pubmed/22851927
http://dx.doi.org/10.3390/md10071572
Descripción
Sumario:Seven new sesquiterpenoids, lochmolins A–G (1–7), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1–4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells.

Ejemplares similares