Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes

Seven new sesquiterpenoids, lochmolins A–G (1–7), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1–4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protei...

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Autores principales: Tseng, Yen-Ju, Shen, Kuo-Ping, Lin, Hui-Li, Huang, Chiung-Yao, Dai, Chang-Feng, Sheu, Jyh-Horng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407932/
https://www.ncbi.nlm.nih.gov/pubmed/22851927
http://dx.doi.org/10.3390/md10071572
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author Tseng, Yen-Ju
Shen, Kuo-Ping
Lin, Hui-Li
Huang, Chiung-Yao
Dai, Chang-Feng
Sheu, Jyh-Horng
author_facet Tseng, Yen-Ju
Shen, Kuo-Ping
Lin, Hui-Li
Huang, Chiung-Yao
Dai, Chang-Feng
Sheu, Jyh-Horng
author_sort Tseng, Yen-Ju
collection PubMed
description Seven new sesquiterpenoids, lochmolins A–G (1–7), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1–4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells.
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spelling pubmed-34079322012-07-31 Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes Tseng, Yen-Ju Shen, Kuo-Ping Lin, Hui-Li Huang, Chiung-Yao Dai, Chang-Feng Sheu, Jyh-Horng Mar Drugs Article Seven new sesquiterpenoids, lochmolins A–G (1–7), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1–4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells. MDPI 2012-07-20 /pmc/articles/PMC3407932/ /pubmed/22851927 http://dx.doi.org/10.3390/md10071572 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Tseng, Yen-Ju
Shen, Kuo-Ping
Lin, Hui-Li
Huang, Chiung-Yao
Dai, Chang-Feng
Sheu, Jyh-Horng
Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes
title Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes
title_full Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes
title_fullStr Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes
title_full_unstemmed Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes
title_short Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes
title_sort lochmolins a–g, new sesquiterpenoids from the soft coral sinularia lochmodes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407932/
https://www.ncbi.nlm.nih.gov/pubmed/22851927
http://dx.doi.org/10.3390/md10071572
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