Novel APP/Aβ mutation K16N produces highly toxic heteromeric Aβ oligomers

Here, we describe a novel missense mutation in the amyloid precursor protein (APP) causing a lysine-to-asparagine substitution at position 687 (APP770; herein, referred to as K16N according to amyloid-β (Aβ) numbering) resulting in an early onset dementia with an autosomal dominant inheritance patte...

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Detalles Bibliográficos
Autores principales: Kaden, Daniela, Harmeier, Anja, Weise, Christoph, Munter, Lisa M, Althoff, Veit, Rost, Benjamin R, Hildebrand, Peter W, Schmitz, Dietmar, Schaefer, Michael, Lurz, Rudi, Skodda, Sabine, Yamamoto, Raina, Arlt, Sönke, Finckh, Ulrich, Multhaup, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407951/
https://www.ncbi.nlm.nih.gov/pubmed/22514144
http://dx.doi.org/10.1002/emmm.201200239

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