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Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection
Neuronal injury during acute viral infection of the brain is associated with the development of persistent cognitive deficits and seizures in humans. In C57BL/6 mice acutely infected with the Theiler's murine encephalomyelitis virus, hippocampal CA1 neurons are injured by a rapid innate immune...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408132/ https://www.ncbi.nlm.nih.gov/pubmed/22848791 http://dx.doi.org/10.1038/srep00545 |
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author | Howe, Charles L. LaFrance-Corey, Reghann G. Sundsbak, Rhianna S. Sauer, Brian M. LaFrance, Stephanie J. Buenz, Eric J. Schmalstieg, William F. |
author_facet | Howe, Charles L. LaFrance-Corey, Reghann G. Sundsbak, Rhianna S. Sauer, Brian M. LaFrance, Stephanie J. Buenz, Eric J. Schmalstieg, William F. |
author_sort | Howe, Charles L. |
collection | PubMed |
description | Neuronal injury during acute viral infection of the brain is associated with the development of persistent cognitive deficits and seizures in humans. In C57BL/6 mice acutely infected with the Theiler's murine encephalomyelitis virus, hippocampal CA1 neurons are injured by a rapid innate immune response, resulting in profound memory deficits. In contrast, infected SJL and B6xSJL F1 hybrid mice exhibit essentially complete hippocampal and memory preservation. Analysis of brain-infiltrating leukocytes revealed that SJL mice mount a sharply attenuated inflammatory monocyte response as compared to B6 mice. Bone marrow transplantation experiments isolated the attenuation to the SJL immune system. Adoptive transfer of B6 inflammatory monocytes into acutely infected B6xSJL hosts converted these mice to a hippocampal damage phenotype and induced a cognitive deficit marked by failure to recognize a novel object. These findings show that inflammatory monocytes are the critical cellular mediator of hippocampal injury during acute picornavirus infection of the brain. |
format | Online Article Text |
id | pubmed-3408132 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-34081322012-07-30 Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection Howe, Charles L. LaFrance-Corey, Reghann G. Sundsbak, Rhianna S. Sauer, Brian M. LaFrance, Stephanie J. Buenz, Eric J. Schmalstieg, William F. Sci Rep Article Neuronal injury during acute viral infection of the brain is associated with the development of persistent cognitive deficits and seizures in humans. In C57BL/6 mice acutely infected with the Theiler's murine encephalomyelitis virus, hippocampal CA1 neurons are injured by a rapid innate immune response, resulting in profound memory deficits. In contrast, infected SJL and B6xSJL F1 hybrid mice exhibit essentially complete hippocampal and memory preservation. Analysis of brain-infiltrating leukocytes revealed that SJL mice mount a sharply attenuated inflammatory monocyte response as compared to B6 mice. Bone marrow transplantation experiments isolated the attenuation to the SJL immune system. Adoptive transfer of B6 inflammatory monocytes into acutely infected B6xSJL hosts converted these mice to a hippocampal damage phenotype and induced a cognitive deficit marked by failure to recognize a novel object. These findings show that inflammatory monocytes are the critical cellular mediator of hippocampal injury during acute picornavirus infection of the brain. Nature Publishing Group 2012-07-30 /pmc/articles/PMC3408132/ /pubmed/22848791 http://dx.doi.org/10.1038/srep00545 Text en Copyright © 2012, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Howe, Charles L. LaFrance-Corey, Reghann G. Sundsbak, Rhianna S. Sauer, Brian M. LaFrance, Stephanie J. Buenz, Eric J. Schmalstieg, William F. Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection |
title | Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection |
title_full | Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection |
title_fullStr | Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection |
title_full_unstemmed | Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection |
title_short | Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection |
title_sort | hippocampal protection in mice with an attenuated inflammatory monocyte response to acute cns picornavirus infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408132/ https://www.ncbi.nlm.nih.gov/pubmed/22848791 http://dx.doi.org/10.1038/srep00545 |
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