Neonatal diabetes mellitus and congenital diaphragmatic hernia: coincidence or concurrent etiology?

Neonatal diabetes mellitus (NDM) is a rare metabolic disorder, affecting approximately 1 in 500,000 live births. The management of NDM is challenging, as the benefits of controlling hyperglycemia must be balanced with the risks of iatrogenic hypoglycemia. NDM occurs in both permanent and transient f...

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Autores principales: Topiol, Emmanuelle S, Minarich, Laurie A, Williams, Charles A, Zori, Roberto T, Kays, David W, Haller, Michael J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408326/
https://www.ncbi.nlm.nih.gov/pubmed/22781086
http://dx.doi.org/10.1186/1687-9856-2012-21
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author Topiol, Emmanuelle S
Minarich, Laurie A
Williams, Charles A
Zori, Roberto T
Kays, David W
Haller, Michael J
author_facet Topiol, Emmanuelle S
Minarich, Laurie A
Williams, Charles A
Zori, Roberto T
Kays, David W
Haller, Michael J
author_sort Topiol, Emmanuelle S
collection PubMed
description Neonatal diabetes mellitus (NDM) is a rare metabolic disorder, affecting approximately 1 in 500,000 live births. The management of NDM is challenging, as the benefits of controlling hyperglycemia must be balanced with the risks of iatrogenic hypoglycemia. NDM occurs in both permanent and transient forms, which have been genetically and phenotypically well characterized. Herein, we present the previously unreported combination of transient NDM (TNDM) and congenital diaphragmatic hernia (CDH). In addition to reviewing the management and genetics of NDM we discuss the potential for overlapping genetic or embryologic abnormalities to explain the concurrence of CDH and NDM.
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spelling pubmed-34083262012-07-31 Neonatal diabetes mellitus and congenital diaphragmatic hernia: coincidence or concurrent etiology? Topiol, Emmanuelle S Minarich, Laurie A Williams, Charles A Zori, Roberto T Kays, David W Haller, Michael J Int J Pediatr Endocrinol Case Report Neonatal diabetes mellitus (NDM) is a rare metabolic disorder, affecting approximately 1 in 500,000 live births. The management of NDM is challenging, as the benefits of controlling hyperglycemia must be balanced with the risks of iatrogenic hypoglycemia. NDM occurs in both permanent and transient forms, which have been genetically and phenotypically well characterized. Herein, we present the previously unreported combination of transient NDM (TNDM) and congenital diaphragmatic hernia (CDH). In addition to reviewing the management and genetics of NDM we discuss the potential for overlapping genetic or embryologic abnormalities to explain the concurrence of CDH and NDM. BioMed Central 2012 2012-07-10 /pmc/articles/PMC3408326/ /pubmed/22781086 http://dx.doi.org/10.1186/1687-9856-2012-21 Text en Copyright ©2012 Topiol et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Topiol, Emmanuelle S
Minarich, Laurie A
Williams, Charles A
Zori, Roberto T
Kays, David W
Haller, Michael J
Neonatal diabetes mellitus and congenital diaphragmatic hernia: coincidence or concurrent etiology?
title Neonatal diabetes mellitus and congenital diaphragmatic hernia: coincidence or concurrent etiology?
title_full Neonatal diabetes mellitus and congenital diaphragmatic hernia: coincidence or concurrent etiology?
title_fullStr Neonatal diabetes mellitus and congenital diaphragmatic hernia: coincidence or concurrent etiology?
title_full_unstemmed Neonatal diabetes mellitus and congenital diaphragmatic hernia: coincidence or concurrent etiology?
title_short Neonatal diabetes mellitus and congenital diaphragmatic hernia: coincidence or concurrent etiology?
title_sort neonatal diabetes mellitus and congenital diaphragmatic hernia: coincidence or concurrent etiology?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408326/
https://www.ncbi.nlm.nih.gov/pubmed/22781086
http://dx.doi.org/10.1186/1687-9856-2012-21
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