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Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin

BACKGROUND: Statins have several effects beyond their well-known antihyperlipidemic activity, which include immunomodulatory, antioxidative and anticoagulant effects. In this study, we have tested the possible antimicrobial activity of statins against a range of standard bacterial strains and bacter...

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Autores principales: Masadeh, Majed, Mhaidat, Nizar, Alzoubi, Karem, Al-azzam, Sayer, Alnasser, Ziad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408379/
https://www.ncbi.nlm.nih.gov/pubmed/22564676
http://dx.doi.org/10.1186/1476-0711-11-13
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author Masadeh, Majed
Mhaidat, Nizar
Alzoubi, Karem
Al-azzam, Sayer
Alnasser, Ziad
author_facet Masadeh, Majed
Mhaidat, Nizar
Alzoubi, Karem
Al-azzam, Sayer
Alnasser, Ziad
author_sort Masadeh, Majed
collection PubMed
description BACKGROUND: Statins have several effects beyond their well-known antihyperlipidemic activity, which include immunomodulatory, antioxidative and anticoagulant effects. In this study, we have tested the possible antimicrobial activity of statins against a range of standard bacterial strains and bacterial clinical isolates. METHODS: Minimum inhibitory concentrations (MIC) values were evaluated and compared among three members of the statins drug (atorvastatin, simvastatin, and rosuvastatin). RESULTS: It was revealed that statins are able to induce variable degrees of antibacterial activity with atorvastatin, and simvastatin being the more potent than rosuvastatin. Methicillin-sensitive staphylococcus aureus (MSSA), methicillin-resistant staphylococcus aureus (MRSA), vancomycin-susceptible enterococci (VSE), vancomycin-resistant enterococcus (VRE), acinetobacter baumannii, staphylococcus epidermidis, and enterobacter aerogenes, were more sensitive to both atorvastatin, and simvastatin compared to rosuvastatin. On the other hand, escherichia coli, proteus mirabilis, and enterobacter cloacae were more sensitive to atorvastatin compared to both simvastatin and rosuvastatin. Furthermore, most clinical isolates were less sensitive to statins compared to their corresponding standard strains. CONCLUSION: Our findings might raise the possibility of a potentially important antibacterial class effect for statins especially, atorvastatin and simvastatin.
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spelling pubmed-34083792012-07-31 Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin Masadeh, Majed Mhaidat, Nizar Alzoubi, Karem Al-azzam, Sayer Alnasser, Ziad Ann Clin Microbiol Antimicrob Research BACKGROUND: Statins have several effects beyond their well-known antihyperlipidemic activity, which include immunomodulatory, antioxidative and anticoagulant effects. In this study, we have tested the possible antimicrobial activity of statins against a range of standard bacterial strains and bacterial clinical isolates. METHODS: Minimum inhibitory concentrations (MIC) values were evaluated and compared among three members of the statins drug (atorvastatin, simvastatin, and rosuvastatin). RESULTS: It was revealed that statins are able to induce variable degrees of antibacterial activity with atorvastatin, and simvastatin being the more potent than rosuvastatin. Methicillin-sensitive staphylococcus aureus (MSSA), methicillin-resistant staphylococcus aureus (MRSA), vancomycin-susceptible enterococci (VSE), vancomycin-resistant enterococcus (VRE), acinetobacter baumannii, staphylococcus epidermidis, and enterobacter aerogenes, were more sensitive to both atorvastatin, and simvastatin compared to rosuvastatin. On the other hand, escherichia coli, proteus mirabilis, and enterobacter cloacae were more sensitive to atorvastatin compared to both simvastatin and rosuvastatin. Furthermore, most clinical isolates were less sensitive to statins compared to their corresponding standard strains. CONCLUSION: Our findings might raise the possibility of a potentially important antibacterial class effect for statins especially, atorvastatin and simvastatin. BioMed Central 2012-05-07 /pmc/articles/PMC3408379/ /pubmed/22564676 http://dx.doi.org/10.1186/1476-0711-11-13 Text en Copyright ©2012 Masadeh et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Masadeh, Majed
Mhaidat, Nizar
Alzoubi, Karem
Al-azzam, Sayer
Alnasser, Ziad
Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin
title Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin
title_full Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin
title_fullStr Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin
title_full_unstemmed Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin
title_short Antibacterial activity of statins: a comparative study of Atorvastatin, Simvastatin, and Rosuvastatin
title_sort antibacterial activity of statins: a comparative study of atorvastatin, simvastatin, and rosuvastatin
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408379/
https://www.ncbi.nlm.nih.gov/pubmed/22564676
http://dx.doi.org/10.1186/1476-0711-11-13
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