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Developmental Role of Zebrafish Protease-Activated Receptor 1 (PAR1) in the Cardio-Vascular System

Thrombin receptor, F2R or PAR1 is a G-protein coupled receptor, located in the membrane of endothelial cells. It has been initially found to transduce signals in hemostasis, but recently also known to act in cancer and in vascular development. Mouse embryos lacking PAR1 function die from hemorrhages...

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Detalles Bibliográficos
Autores principales: Ellertsdottir, Elin, Berthold, Peter R., Bouzaffour, Mohamed, Dufourcq, Pascale, Trayer, Vincent, Gauron, Carole, Vriz, Sophie, Affolter, Markus, Rampon, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408399/
https://www.ncbi.nlm.nih.gov/pubmed/22860064
http://dx.doi.org/10.1371/journal.pone.0042131