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Cyclic AMP regulates formation of mammary epithelial acini in vitro

Epithelial cells form tubular and acinar structures notable for a hollow lumen. In three-dimensional culture utilizing MCF10A mammary epithelial cells, acini form due to integrin-dependent polarization and survival of cells contacting extracellular matrix (ECM), and the apoptosis of inner cells of a...

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Detalles Bibliográficos
Autores principales: Nedvetsky, Pavel I., Kwon, Sang-Ho, Debnath, Jayanta, Mostov, Keith E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408423/
https://www.ncbi.nlm.nih.gov/pubmed/22675028
http://dx.doi.org/10.1091/mbc.E12-02-0078