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Oleanolic Acid Reduces Hyperglycemia beyond Treatment Period with Akt/FoxO1-Induced Suppression of Hepatic Gluconeogenesis in Type-2 Diabetic Mice

The present study investigated the chronic efficacy of oleanolic acid (OA), a triterpenoid selected from our recent screening, on hyperglycemia in type-2 diabetic mice. C57BL/6J mice were fed a high-fat diet followed by low doses of streptozotocin to generate a type-2 diabetic model. OA (100 mg/kg/d...

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Detalles Bibliográficos
Autores principales:	Zeng, Xiao-Yi, Wang, Yi-Ping, Cantley, James, Iseli, Tristan J., Molero, Juan Carlos, Hegarty, Bronwyn D., Kraegen, Edward W., Ye, Yang, Ye, Ji-Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408432/ https://www.ncbi.nlm.nih.gov/pubmed/22860063 http://dx.doi.org/10.1371/journal.pone.0042115

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