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Mapping Paratope on Antithrombotic Antibody 6B4 to Epitope on Platelet Glycoprotein Ibalpha via Molecular Dynamic Simulations

Binding of platelet receptor glycoprotein Ibα (GPIbα) to the A1 domain of von Willebrand factor (vWF) is a critical step in both physiologic hemostasis and pathologic thrombosis, for initiating platelet adhesion to subendothelium of blood vessels at sites of vascular injury. Gain-of-function mutatio...

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Detalles Bibliográficos
Autores principales: Fang, Xiang, Fang, Ying, Liu, Li, Liu, Guangjian, Wu, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408434/
https://www.ncbi.nlm.nih.gov/pubmed/22860101
http://dx.doi.org/10.1371/journal.pone.0042263

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