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Nanoparticle-Mediated Local Delivery of an Antisense TGF-β1 Construct Inhibits Intimal Hyperplasia in Autogenous Vein Grafts in Rats

BACKGROUND: Intimal hyperplasia is one of the most important causes of vascular graft failure. Numerous studies have correlated transforming growth factor-β1 (TGF-β1) with extracellular matrix (ECM) deposition, a hallmark of intimal thickening. PRINCIPAL FINDINGS: In the present study, we performed...

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Detalles Bibliográficos
Autores principales:	Sun, Da-Xin, Liu, Zhen, Tan, Xiao-Dong, Cui, Dong-Xu, Wang, Bao-Sheng, Dai, Xian-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408488/ https://www.ncbi.nlm.nih.gov/pubmed/22860019 http://dx.doi.org/10.1371/journal.pone.0041857

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