TMPRSS2- Driven ERG Expression In Vivo Increases Self-Renewal and Maintains Expression in a Castration Resistant Subpopulation

Genomic rearrangements commonly occur in many types of cancers and often initiate or alter the progression of disease. Here we describe an in vivo mouse model that recapitulates the most frequent rearrangement in prostate cancer, the fusion of the promoter region of TMPRSS2 with the coding region of...

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Detalles Bibliográficos
Autores principales: Casey, Orla M., Fang, Lei, Hynes, Paul G., Abou-Kheir, Wassim G., Martin, Philip L., Tillman, Heather S., Petrovics, Gyorgy, Awwad, Hibah O., Ward, Yvona, Lake, Ross, Zhang, Luhua, Kelly, Kathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408501/
https://www.ncbi.nlm.nih.gov/pubmed/22860005
http://dx.doi.org/10.1371/journal.pone.0041668

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