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Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

The IRE1α-XBP1 pathway, a key component of the endoplasmic reticulum (ER) stress response, is considered to be a critical regulator for survival of multiple myeloma (MM) cells. Therefore, the availability of small-molecule inhibitors targeting this pathway would offer a new chemotherapeutic strategy...

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Detalles Bibliográficos
Autores principales:	Ri, M, Tashiro, E, Oikawa, D, Shinjo, S, Tokuda, M, Yokouchi, Y, Narita, T, Masaki, A, Ito, A, Ding, J, Kusumoto, S, Ishida, T, Komatsu, H, Shiotsu, Y, Ueda, R, Iwawaki, T, Imoto, M, Iida, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408640/ https://www.ncbi.nlm.nih.gov/pubmed/22852048 http://dx.doi.org/10.1038/bcj.2012.26

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