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Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa)

Aims. To determine the usefulness of platelet count (PC), spleen diameter (SD) and platelet count/spleen diameter ratio (PC/SD ratio) for the prediction of oesophageal varices (OV) and large OV in black African patients with cirrhosis in Côte d'Ivoire. Materials and Methods. Study was conducted...

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Autores principales: Mahassadi, Alassan Kouamé, Bathaix, Fulgence Yao, Assi, Constant, Bangoura, Aboubacar Demba, Allah-Kouadio, Emile, Kissi, Henriette Ya, Touré, Abdoulaye, Doffou, Stanislas, Konaté, Issa, Attia, Alain Koffi, Camara, Mathieu Benoit, Ndri-Yoman, Thérèse Aya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408675/
https://www.ncbi.nlm.nih.gov/pubmed/22888334
http://dx.doi.org/10.1155/2012/216390
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author Mahassadi, Alassan Kouamé
Bathaix, Fulgence Yao
Assi, Constant
Bangoura, Aboubacar Demba
Allah-Kouadio, Emile
Kissi, Henriette Ya
Touré, Abdoulaye
Doffou, Stanislas
Konaté, Issa
Attia, Alain Koffi
Camara, Mathieu Benoit
Ndri-Yoman, Thérèse Aya
author_facet Mahassadi, Alassan Kouamé
Bathaix, Fulgence Yao
Assi, Constant
Bangoura, Aboubacar Demba
Allah-Kouadio, Emile
Kissi, Henriette Ya
Touré, Abdoulaye
Doffou, Stanislas
Konaté, Issa
Attia, Alain Koffi
Camara, Mathieu Benoit
Ndri-Yoman, Thérèse Aya
author_sort Mahassadi, Alassan Kouamé
collection PubMed
description Aims. To determine the usefulness of platelet count (PC), spleen diameter (SD) and platelet count/spleen diameter ratio (PC/SD ratio) for the prediction of oesophageal varices (OV) and large OV in black African patients with cirrhosis in Côte d'Ivoire. Materials and Methods. Study was conducted in a training sample (111 patients) and in a validation sample (91 patients). Results. Factors predicting OV were sex: (OR = 0.08, P = 0.0003), PC (OR = 12.4, P = 0.0003), SD (OR = 1.04, P = 0.002) in the training sample. The AUROCs (±SE) of the model (cutoff ≥ 0.6), PC (cutoff < 110500), SD (cutoff > 140) and PC/SD ratio (cutoff ≤ 868) were, respectively; 0.879 ± 0.04, 0.768 ± 0.06, 0.679 ± 0.06, 0.793 ± 0.06. For the prediction of large OV, the model's AUROC (0.850 ± 0.05) was superior to that of PC (0.688 ± 0.06), SD (0.732 ± 0.05) and PC/SD ratio (0.752 ± 0.06). In the validation sample, with PC, PC/SD ratio and the model, upper digestive endoscopy could be obviated respectively in 45.1, 45.1, and 44% of cirrhotic patients. Prophylactic treatment with beta blockers could be started undoubtedly respectively in 36.3, 41.8 and 28.6% of them as having large OV. Conclusion. Non-invasive means could be used to monitor cirrhotic patients and consider treatment in African regions lacking endoscopic facilities.
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spelling pubmed-34086752012-08-10 Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa) Mahassadi, Alassan Kouamé Bathaix, Fulgence Yao Assi, Constant Bangoura, Aboubacar Demba Allah-Kouadio, Emile Kissi, Henriette Ya Touré, Abdoulaye Doffou, Stanislas Konaté, Issa Attia, Alain Koffi Camara, Mathieu Benoit Ndri-Yoman, Thérèse Aya Gastroenterol Res Pract Clinical Study Aims. To determine the usefulness of platelet count (PC), spleen diameter (SD) and platelet count/spleen diameter ratio (PC/SD ratio) for the prediction of oesophageal varices (OV) and large OV in black African patients with cirrhosis in Côte d'Ivoire. Materials and Methods. Study was conducted in a training sample (111 patients) and in a validation sample (91 patients). Results. Factors predicting OV were sex: (OR = 0.08, P = 0.0003), PC (OR = 12.4, P = 0.0003), SD (OR = 1.04, P = 0.002) in the training sample. The AUROCs (±SE) of the model (cutoff ≥ 0.6), PC (cutoff < 110500), SD (cutoff > 140) and PC/SD ratio (cutoff ≤ 868) were, respectively; 0.879 ± 0.04, 0.768 ± 0.06, 0.679 ± 0.06, 0.793 ± 0.06. For the prediction of large OV, the model's AUROC (0.850 ± 0.05) was superior to that of PC (0.688 ± 0.06), SD (0.732 ± 0.05) and PC/SD ratio (0.752 ± 0.06). In the validation sample, with PC, PC/SD ratio and the model, upper digestive endoscopy could be obviated respectively in 45.1, 45.1, and 44% of cirrhotic patients. Prophylactic treatment with beta blockers could be started undoubtedly respectively in 36.3, 41.8 and 28.6% of them as having large OV. Conclusion. Non-invasive means could be used to monitor cirrhotic patients and consider treatment in African regions lacking endoscopic facilities. Hindawi Publishing Corporation 2012 2012-07-22 /pmc/articles/PMC3408675/ /pubmed/22888334 http://dx.doi.org/10.1155/2012/216390 Text en Copyright © 2012 Alassan Kouamé Mahassadi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Mahassadi, Alassan Kouamé
Bathaix, Fulgence Yao
Assi, Constant
Bangoura, Aboubacar Demba
Allah-Kouadio, Emile
Kissi, Henriette Ya
Touré, Abdoulaye
Doffou, Stanislas
Konaté, Issa
Attia, Alain Koffi
Camara, Mathieu Benoit
Ndri-Yoman, Thérèse Aya
Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa)
title Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa)
title_full Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa)
title_fullStr Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa)
title_full_unstemmed Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa)
title_short Usefulness of Noninvasive Predictors of Oesophageal Varices in Black African Cirrhotic Patients in Côte d'Ivoire (West Africa)
title_sort usefulness of noninvasive predictors of oesophageal varices in black african cirrhotic patients in côte d'ivoire (west africa)
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408675/
https://www.ncbi.nlm.nih.gov/pubmed/22888334
http://dx.doi.org/10.1155/2012/216390
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