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Contribution of the TGFB1 Gene 
to Myocardial Infarction Susceptibility


Carriage frequencies of alleles and genotypes of theTGFB1 gene polymorphous loci –509C>T (rs1800469), 869T>C (rs1982073), 915G>C (rs1800471), which affect the level of cytokine TGF-β1 production, were analyzed in the patients of Russian ethnic descent with myocardial infarction (MI) (406 ca...

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Autores principales: Barsova, R.M., Titov, B.V., Matveeva, N.A., Favorov, A.V., Sukhinina, T.S., Shahnovich, R.M., Ruda, M.Ia., Favorova, O.O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408705/
https://www.ncbi.nlm.nih.gov/pubmed/22872813
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author Barsova, R.M.
Titov, B.V.
Matveeva, N.A.
Favorov, A.V.
Sukhinina, T.S.
Shahnovich, R.M.
Ruda, M.Ia.
Favorova, O.O.
author_facet Barsova, R.M.
Titov, B.V.
Matveeva, N.A.
Favorov, A.V.
Sukhinina, T.S.
Shahnovich, R.M.
Ruda, M.Ia.
Favorova, O.O.
author_sort Barsova, R.M.
collection PubMed
description Carriage frequencies of alleles and genotypes of theTGFB1 gene polymorphous loci –509C>T (rs1800469), 869T>C (rs1982073), 915G>C (rs1800471), which affect the level of cytokine TGF-β1 production, were analyzed in the patients of Russian ethnic descent with myocardial infarction (MI) (406 cases) and in the control group of the same ethnic descent (198 controls). Significant association with MI was observed in carriage frequencies of the alleleTGFB1*–509T (p=0.046, OR =1.45, 95% CI: 1.02-2.06), genotypes TGFB1*869T/T (p=0.0024, OR =1.75, 95% CI: 1.22-2.51), andTGFB1*915G/G (p=0.048, OR=1.76, 95% CI: 1.05-2.97). Linkage disequilibrium analysis for these SNPs has shown that the associations revealed can be considered to be independent. A complex analysis of MI association with combinations of alleles/genotypes of said SNPs indicates their cumulative effect. An analysis of susceptibility to early-onset MI (≤ 50 years old) revealed a positive association of the alleleTGFB1*–509T (p=0.002, OR=2.24, 95% CI: 1.35-3.71) and genotypeTGFB1*869T/T (p=0.008, OR=1.93, 95% CI: 1.18-3.15), as well as their additivity. An analysis of susceptibility to recurrent MI revealed an association of the genotypeTGFB1*–509T/T (p=0.0078, OR=2.60, 95% CI: 1.28-5.28). The results obtained indicate the important role of theTGFB1gene in susceptibility to MI, including early-onset and recurrent MI, in Russians.
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spelling pubmed-34087052012-08-07 Contribution of the TGFB1 Gene 
to Myocardial Infarction Susceptibility
 Barsova, R.M. Titov, B.V. Matveeva, N.A. Favorov, A.V. Sukhinina, T.S. Shahnovich, R.M. Ruda, M.Ia. Favorova, O.O. Acta Naturae Research Article Carriage frequencies of alleles and genotypes of theTGFB1 gene polymorphous loci –509C>T (rs1800469), 869T>C (rs1982073), 915G>C (rs1800471), which affect the level of cytokine TGF-β1 production, were analyzed in the patients of Russian ethnic descent with myocardial infarction (MI) (406 cases) and in the control group of the same ethnic descent (198 controls). Significant association with MI was observed in carriage frequencies of the alleleTGFB1*–509T (p=0.046, OR =1.45, 95% CI: 1.02-2.06), genotypes TGFB1*869T/T (p=0.0024, OR =1.75, 95% CI: 1.22-2.51), andTGFB1*915G/G (p=0.048, OR=1.76, 95% CI: 1.05-2.97). Linkage disequilibrium analysis for these SNPs has shown that the associations revealed can be considered to be independent. A complex analysis of MI association with combinations of alleles/genotypes of said SNPs indicates their cumulative effect. An analysis of susceptibility to early-onset MI (≤ 50 years old) revealed a positive association of the alleleTGFB1*–509T (p=0.002, OR=2.24, 95% CI: 1.35-3.71) and genotypeTGFB1*869T/T (p=0.008, OR=1.93, 95% CI: 1.18-3.15), as well as their additivity. An analysis of susceptibility to recurrent MI revealed an association of the genotypeTGFB1*–509T/T (p=0.0078, OR=2.60, 95% CI: 1.28-5.28). The results obtained indicate the important role of theTGFB1gene in susceptibility to MI, including early-onset and recurrent MI, in Russians. A.I. Gordeyev 2012 /pmc/articles/PMC3408705/ /pubmed/22872813 Text en Copyright © 2012 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Barsova, R.M.
Titov, B.V.
Matveeva, N.A.
Favorov, A.V.
Sukhinina, T.S.
Shahnovich, R.M.
Ruda, M.Ia.
Favorova, O.O.
Contribution of the TGFB1 Gene 
to Myocardial Infarction Susceptibility

title Contribution of the TGFB1 Gene 
to Myocardial Infarction Susceptibility

title_full Contribution of the TGFB1 Gene 
to Myocardial Infarction Susceptibility

title_fullStr Contribution of the TGFB1 Gene 
to Myocardial Infarction Susceptibility

title_full_unstemmed Contribution of the TGFB1 Gene 
to Myocardial Infarction Susceptibility

title_short Contribution of the TGFB1 Gene 
to Myocardial Infarction Susceptibility

title_sort contribution of the tgfb1 gene 
to myocardial infarction susceptibility

topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408705/
https://www.ncbi.nlm.nih.gov/pubmed/22872813
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