Recombinant Human Cyclophilin A in vitro Inhibits the Formation of Fibrin Clot


The chemotactic properties of cyclophilin A are well-known. There exists however a poor level of understanding regarding the hemostatic effects of this protein. Herein it is shown that recombinant human cyclophilin A (rhСyA), in contrast to the granulocyte colony-stimulating factor, is capable of in...

Descripción completa

Detalles Bibliográficos
Autores principales: Morozov, Yu.A., Khromykh, L.M., Dementieva, I.I., Charnaia, M.A., Kulikova, N.L., Kazansky, 
D.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408707/
https://www.ncbi.nlm.nih.gov/pubmed/22880163
Descripción
Sumario:The chemotactic properties of cyclophilin A are well-known. There exists however a poor level of understanding regarding the hemostatic effects of this protein. Herein it is shown that recombinant human cyclophilin A (rhСyA), in contrast to the granulocyte colony-stimulating factor, is capable of inhibitingin vitrothe formation of a fibrin clot, thereby violating the spatial dynamics of clot growth; this effect is transient and dose-independent. Furthermore, the hypothesis that the conformational changes in the thrombin–rhCyA complex may mediate the anticoagulant effect of rhCyA on the autowave processes of blood clotting is postulated.

Ejemplares similares