Recombinant Human Cyclophilin A in vitro Inhibits the Formation of Fibrin Clot


The chemotactic properties of cyclophilin A are well-known. There exists however a poor level of understanding regarding the hemostatic effects of this protein. Herein it is shown that recombinant human cyclophilin A (rhСyA), in contrast to the granulocyte colony-stimulating factor, is capable of in...

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Autores principales: Morozov, Yu.A., Khromykh, L.M., Dementieva, I.I., Charnaia, M.A., Kulikova, N.L., Kazansky, 
D.B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: A.I. Gordeyev 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408707/
https://www.ncbi.nlm.nih.gov/pubmed/22880163
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author Morozov, Yu.A.
Khromykh, L.M.
Dementieva, I.I.
Charnaia, M.A.
Kulikova, N.L.
Kazansky, 
D.B.
author_facet Morozov, Yu.A.
Khromykh, L.M.
Dementieva, I.I.
Charnaia, M.A.
Kulikova, N.L.
Kazansky, 
D.B.
author_sort Morozov, Yu.A.
collection PubMed
description The chemotactic properties of cyclophilin A are well-known. There exists however a poor level of understanding regarding the hemostatic effects of this protein. Herein it is shown that recombinant human cyclophilin A (rhСyA), in contrast to the granulocyte colony-stimulating factor, is capable of inhibitingin vitrothe formation of a fibrin clot, thereby violating the spatial dynamics of clot growth; this effect is transient and dose-independent. Furthermore, the hypothesis that the conformational changes in the thrombin–rhCyA complex may mediate the anticoagulant effect of rhCyA on the autowave processes of blood clotting is postulated.
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spelling pubmed-34087072012-08-09 Recombinant Human Cyclophilin A in vitro Inhibits the Formation of Fibrin Clot
 Morozov, Yu.A. Khromykh, L.M. Dementieva, I.I. Charnaia, M.A. Kulikova, N.L. Kazansky, 
D.B. Acta Naturae Research Article The chemotactic properties of cyclophilin A are well-known. There exists however a poor level of understanding regarding the hemostatic effects of this protein. Herein it is shown that recombinant human cyclophilin A (rhСyA), in contrast to the granulocyte colony-stimulating factor, is capable of inhibitingin vitrothe formation of a fibrin clot, thereby violating the spatial dynamics of clot growth; this effect is transient and dose-independent. Furthermore, the hypothesis that the conformational changes in the thrombin–rhCyA complex may mediate the anticoagulant effect of rhCyA on the autowave processes of blood clotting is postulated. A.I. Gordeyev 2012 /pmc/articles/PMC3408707/ /pubmed/22880163 Text en Copyright © 2012 Park-media Ltd. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Morozov, Yu.A.
Khromykh, L.M.
Dementieva, I.I.
Charnaia, M.A.
Kulikova, N.L.
Kazansky, 
D.B.
Recombinant Human Cyclophilin A in vitro Inhibits the Formation of Fibrin Clot

title Recombinant Human Cyclophilin A in vitro Inhibits the Formation of Fibrin Clot

title_full Recombinant Human Cyclophilin A in vitro Inhibits the Formation of Fibrin Clot

title_fullStr Recombinant Human Cyclophilin A in vitro Inhibits the Formation of Fibrin Clot

title_full_unstemmed Recombinant Human Cyclophilin A in vitro Inhibits the Formation of Fibrin Clot

title_short Recombinant Human Cyclophilin A in vitro Inhibits the Formation of Fibrin Clot

title_sort recombinant human cyclophilin a in vitro inhibits the formation of fibrin clot

topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408707/
https://www.ncbi.nlm.nih.gov/pubmed/22880163
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