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Syndecan-4 independently regulates multiple small GTPases to promote fibroblast migration during wound healing
Upon wounding, syndecan-4 detects the appearance of fibronectin in the wound bed and mediates regulation of the small GTPases, Rac1, RhoA and RhoG. Cohesive regulation of these molecules results in cycles of membrane protrusion and cytoskeletal contraction, and triggers the endocytosis of α(5)β(1)-i...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408980/ https://www.ncbi.nlm.nih.gov/pubmed/22790193 http://dx.doi.org/10.4161/sgtp.19301 |