Does rosuvastatin increase serum levels of 25-hydroxy-vitamin D?

An observational study and a “clinical trial” seem to prove that rosuvastatin (but not fluvastatin) dramatically increases serum levels of 25-(OH)-D3 (three-fold above starting values). A critical analysis of the two publications, presented below, raises serious concerns. Conclusions from these two...

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Detalles Bibliográficos
Autores principales: Glossmann, Hartmut H., Blumthaler, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
For Debate
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408988/
https://www.ncbi.nlm.nih.gov/pubmed/22870344
http://dx.doi.org/10.4161/derm.18681
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author Glossmann, Hartmut H.
Blumthaler, Mario
author_facet Glossmann, Hartmut H.
Blumthaler, Mario
author_sort Glossmann, Hartmut H.
collection PubMed
description An observational study and a “clinical trial” seem to prove that rosuvastatin (but not fluvastatin) dramatically increases serum levels of 25-(OH)-D3 (three-fold above starting values). A critical analysis of the two publications, presented below, raises serious concerns. Conclusions from these two studies have already been drawn in the scientific literature.It is argued that claiming or believing in a “novel pleiotropic effect of rosuvastatin” may be misleading and premature.
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spelling pubmed-34089882012-08-06 Does rosuvastatin increase serum levels of 25-hydroxy-vitamin D? Glossmann, Hartmut H. Blumthaler, Mario Dermatoendocrinol For Debate An observational study and a “clinical trial” seem to prove that rosuvastatin (but not fluvastatin) dramatically increases serum levels of 25-(OH)-D3 (three-fold above starting values). A critical analysis of the two publications, presented below, raises serious concerns. Conclusions from these two studies have already been drawn in the scientific literature.It is argued that claiming or believing in a “novel pleiotropic effect of rosuvastatin” may be misleading and premature. Landes Bioscience 2012-01-01 /pmc/articles/PMC3408988/ /pubmed/22870344 http://dx.doi.org/10.4161/derm.18681 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle For Debate
Glossmann, Hartmut H.
Blumthaler, Mario
Does rosuvastatin increase serum levels of 25-hydroxy-vitamin D?
title Does rosuvastatin increase serum levels of 25-hydroxy-vitamin D?
title_full Does rosuvastatin increase serum levels of 25-hydroxy-vitamin D?
title_fullStr Does rosuvastatin increase serum levels of 25-hydroxy-vitamin D?
title_full_unstemmed Does rosuvastatin increase serum levels of 25-hydroxy-vitamin D?
title_short Does rosuvastatin increase serum levels of 25-hydroxy-vitamin D?
title_sort does rosuvastatin increase serum levels of 25-hydroxy-vitamin d?
topic For Debate
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408988/
https://www.ncbi.nlm.nih.gov/pubmed/22870344
http://dx.doi.org/10.4161/derm.18681
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