Folate status of gut microbiome affects Caenorhabditis elegans lifespan

In a paper in BMC Biology Virk et al. show that Caenorhabditis elegans lifespan is extended in response to a diet of folate-deficient Escherichia coli. The deficiencies in folate biosynthesis were due to an aroD mutation, or treatment of E. coli with sulfa drugs, which are mimics of the folate precu...

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Detalles Bibliográficos
Autores principales: Nguyen, Theresa PT, Clarke, Catherine F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409036/
https://www.ncbi.nlm.nih.gov/pubmed/22849295
http://dx.doi.org/10.1186/1741-7007-10-66
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author Nguyen, Theresa PT
Clarke, Catherine F
author_facet Nguyen, Theresa PT
Clarke, Catherine F
author_sort Nguyen, Theresa PT
collection PubMed
description In a paper in BMC Biology Virk et al. show that Caenorhabditis elegans lifespan is extended in response to a diet of folate-deficient Escherichia coli. The deficiencies in folate biosynthesis were due to an aroD mutation, or treatment of E. coli with sulfa drugs, which are mimics of the folate precursor para-aminobenzoic acid. This study suggests that pharmacological manipulation of the gut microbiome folate status may be a viable approach to slow animal aging, and raises questions about folate supplementation. See research article http://www.http://www.biomedcentral.com/1741-7007/10/67
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spelling pubmed-34090362012-08-01 Folate status of gut microbiome affects Caenorhabditis elegans lifespan Nguyen, Theresa PT Clarke, Catherine F BMC Biol Commentary In a paper in BMC Biology Virk et al. show that Caenorhabditis elegans lifespan is extended in response to a diet of folate-deficient Escherichia coli. The deficiencies in folate biosynthesis were due to an aroD mutation, or treatment of E. coli with sulfa drugs, which are mimics of the folate precursor para-aminobenzoic acid. This study suggests that pharmacological manipulation of the gut microbiome folate status may be a viable approach to slow animal aging, and raises questions about folate supplementation. See research article http://www.http://www.biomedcentral.com/1741-7007/10/67 BioMed Central 2012-07-31 /pmc/articles/PMC3409036/ /pubmed/22849295 http://dx.doi.org/10.1186/1741-7007-10-66 Text en Copyright ©2012 Nguyen and Clarke; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Nguyen, Theresa PT
Clarke, Catherine F
Folate status of gut microbiome affects Caenorhabditis elegans lifespan
title Folate status of gut microbiome affects Caenorhabditis elegans lifespan
title_full Folate status of gut microbiome affects Caenorhabditis elegans lifespan
title_fullStr Folate status of gut microbiome affects Caenorhabditis elegans lifespan
title_full_unstemmed Folate status of gut microbiome affects Caenorhabditis elegans lifespan
title_short Folate status of gut microbiome affects Caenorhabditis elegans lifespan
title_sort folate status of gut microbiome affects caenorhabditis elegans lifespan
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409036/
https://www.ncbi.nlm.nih.gov/pubmed/22849295
http://dx.doi.org/10.1186/1741-7007-10-66
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