The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation

BACKGROUND: Several factors contribute to the deterioration in synaptic plasticity which accompanies age and one of these is neuroinflammation. This is characterized by increased microglial activation associated with increased production of proinflammatory cytokines like interleukin-1β (IL-1β). In a...

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Detalles Bibliográficos
Autores principales: Murphy, Niamh, Cowley, Thelma R, Blau, Christoph W, Dempsey, Colin N, Noonan, Janis, Gowran, Aoife, Tanveer, Riffat, Olango, Weredeselam M, Finn, David P, Campbell, Veronica A, Lynch, Marina A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409037/
https://www.ncbi.nlm.nih.gov/pubmed/22537429
http://dx.doi.org/10.1186/1742-2094-9-79

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