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Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid
Severe acute exacerbation or liver failure induced by standard interferon-α(IFN-α) therapy had been reported to occur in few patients with chronic hepatitis B. However, no report showed that pegylated interferon-α therapy was able to induce severe acute exacerbation of chronic hepatitis B. Here, we...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409068/ https://www.ncbi.nlm.nih.gov/pubmed/22828242 http://dx.doi.org/10.1186/1743-422X-9-136 |
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author | Mao, Qing Zhang, Hui-Yan You, Jian-Ping Zhang, Xu-Qing |
author_facet | Mao, Qing Zhang, Hui-Yan You, Jian-Ping Zhang, Xu-Qing |
author_sort | Mao, Qing |
collection | PubMed |
description | Severe acute exacerbation or liver failure induced by standard interferon-α(IFN-α) therapy had been reported to occur in few patients with chronic hepatitis B. However, no report showed that pegylated interferon-α therapy was able to induce severe acute exacerbation of chronic hepatitis B. Here, we describe three patients with severe acute exacerbation of chronic hepatitis B during pegylated interferon-α2a (Pegasys) treatment. One patient progressed into acute-on-chronic liver failure (ACLF) at the second week of Pegasys treatment. Two patients progressed into acute-on-chronic pre-liver failure (pre-ACLF) at the second and eighth week of Pegasys treatment, respectively. Three patients recovered after early combined intervention with corticosteroid and lamivudine. Our data indicated that there was a risk of severe acute exacerbation among patients with chronic hepatitis B during receiving Pegasys treatment. Importantly, early combined intervention with corticosteroid and lamivudine should be introduced to prevent the disease progression and improve their prognosis once severe acute exacerbation was diagnosed. |
format | Online Article Text |
id | pubmed-3409068 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34090682012-08-01 Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid Mao, Qing Zhang, Hui-Yan You, Jian-Ping Zhang, Xu-Qing Virol J Case Report Severe acute exacerbation or liver failure induced by standard interferon-α(IFN-α) therapy had been reported to occur in few patients with chronic hepatitis B. However, no report showed that pegylated interferon-α therapy was able to induce severe acute exacerbation of chronic hepatitis B. Here, we describe three patients with severe acute exacerbation of chronic hepatitis B during pegylated interferon-α2a (Pegasys) treatment. One patient progressed into acute-on-chronic liver failure (ACLF) at the second week of Pegasys treatment. Two patients progressed into acute-on-chronic pre-liver failure (pre-ACLF) at the second and eighth week of Pegasys treatment, respectively. Three patients recovered after early combined intervention with corticosteroid and lamivudine. Our data indicated that there was a risk of severe acute exacerbation among patients with chronic hepatitis B during receiving Pegasys treatment. Importantly, early combined intervention with corticosteroid and lamivudine should be introduced to prevent the disease progression and improve their prognosis once severe acute exacerbation was diagnosed. BioMed Central 2012-07-24 /pmc/articles/PMC3409068/ /pubmed/22828242 http://dx.doi.org/10.1186/1743-422X-9-136 Text en Copyright ©2012 Mao et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Mao, Qing Zhang, Hui-Yan You, Jian-Ping Zhang, Xu-Qing Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid |
title | Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid |
title_full | Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid |
title_fullStr | Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid |
title_full_unstemmed | Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid |
title_short | Severe acute exacerbation of chronic hepatitis B during pegylated interferon treatment and early intervention with corticosteroid |
title_sort | severe acute exacerbation of chronic hepatitis b during pegylated interferon treatment and early intervention with corticosteroid |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409068/ https://www.ncbi.nlm.nih.gov/pubmed/22828242 http://dx.doi.org/10.1186/1743-422X-9-136 |
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