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Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in K(ATP) channels

The ATP-sensitive potassium (K(ATP)) channel consisting of the inward rectifier Kir6.2 and SUR1 (sulfonylurea receptor 1) couples cell metabolism to membrane excitability and regulates insulin secretion. Inhibition by intracellular ATP is a hallmark feature of the channel. ATP sensitivity is conferr...

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Detalles Bibliográficos
Autores principales:	Pratt, Emily B., Zhou, Qing, Gay, Joel W., Shyng, Show-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409095/ https://www.ncbi.nlm.nih.gov/pubmed/22802363 http://dx.doi.org/10.1085/jgp.201210803

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