A Comprehensive Characterization of Genome-Wide Copy Number Aberrations in Colorectal Cancer Reveals Novel Oncogenes and Patterns of Alterations

To develop a comprehensive overview of copy number aberrations (CNAs) in stage-II/III colorectal cancer (CRC), we characterized 302 tumors from the PETACC-3 clinical trial. Microsatellite-stable (MSS) samples (n = 269) had 66 minimal common CNA regions, with frequent gains on 20 q (72.5%), 7 (41.8%)...

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Detalles Bibliográficos
Autores principales: Xie, Tao, d’ Ario, Giovanni, Lamb, John R., Martin, Eric, Wang, Kai, Tejpar, Sabine, Delorenzi, Mauro, Bosman, Fred T., Roth, Arnaud D., Yan, Pu, Bougel, Stephanie, Di Narzo, Antonio Fabio, Popovici, Vlad, Budinská, Eva, Mao, Mao, Weinrich, Scott L., Rejto, Paul A., Hodgson, J. Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409212/
https://www.ncbi.nlm.nih.gov/pubmed/22860045
http://dx.doi.org/10.1371/journal.pone.0042001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409212/
https://www.ncbi.nlm.nih.gov/pubmed/22860045
http://dx.doi.org/10.1371/journal.pone.0042001

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