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A specific role for TLR1 in protective T(H)17 immunity during mucosal infection
The balance between regulatory and inflammatory immune responses is critical to maintain intestinal homeostasis. Furthermore, the nature of the inflammatory response needs to be tailored to the tissue to provide proper protective immunity while preserving host integrity. TLR2 (Toll-like receptor 2)...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409496/ https://www.ncbi.nlm.nih.gov/pubmed/22778390 http://dx.doi.org/10.1084/jem.20112339 |
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author | DePaolo, R. William Kamdar, Karishma Khakpour, Samira Sugiura, Yui Wang, Wenxia Jabri, Bana |
author_facet | DePaolo, R. William Kamdar, Karishma Khakpour, Samira Sugiura, Yui Wang, Wenxia Jabri, Bana |
author_sort | DePaolo, R. William |
collection | PubMed |
description | The balance between regulatory and inflammatory immune responses is critical to maintain intestinal homeostasis. Furthermore, the nature of the inflammatory response needs to be tailored to the tissue to provide proper protective immunity while preserving host integrity. TLR2 (Toll-like receptor 2) is a unique TLR in that it has been shown to promote regulatory and inflammatory T cell responses. Using Yersinia enterocolitica, we show that oral infection promotes T(H)17 immunity, whereas systemic infection promotes T(H)1 immunity. Furthermore, induction of T(H)17 immunity during oral infection is dependent on TLR1 and results from the combinatorial effect of TLR2/TLR1-induced IL-6 and IL-23 and the presence of TGF-β in the intestinal environment. Interestingly, TLR2/TLR1 was not involved in T(H)1 immune responses during systemic infection, whereas the TLR2/TLR6 receptor complex induced IL-10(+) regulatory T cell responses during both systemic and oral infections. Our results reveal that the route of infection is central in determining which pathways provide protective immunity. Furthermore, they also demonstrate that TLR2 has dual immune functions in the gut and identify TLR1 as a critical innate receptor for protective intestinal T(H)17 immunity. |
format | Online Article Text |
id | pubmed-3409496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-34094962013-01-30 A specific role for TLR1 in protective T(H)17 immunity during mucosal infection DePaolo, R. William Kamdar, Karishma Khakpour, Samira Sugiura, Yui Wang, Wenxia Jabri, Bana J Exp Med Brief Definitive Report The balance between regulatory and inflammatory immune responses is critical to maintain intestinal homeostasis. Furthermore, the nature of the inflammatory response needs to be tailored to the tissue to provide proper protective immunity while preserving host integrity. TLR2 (Toll-like receptor 2) is a unique TLR in that it has been shown to promote regulatory and inflammatory T cell responses. Using Yersinia enterocolitica, we show that oral infection promotes T(H)17 immunity, whereas systemic infection promotes T(H)1 immunity. Furthermore, induction of T(H)17 immunity during oral infection is dependent on TLR1 and results from the combinatorial effect of TLR2/TLR1-induced IL-6 and IL-23 and the presence of TGF-β in the intestinal environment. Interestingly, TLR2/TLR1 was not involved in T(H)1 immune responses during systemic infection, whereas the TLR2/TLR6 receptor complex induced IL-10(+) regulatory T cell responses during both systemic and oral infections. Our results reveal that the route of infection is central in determining which pathways provide protective immunity. Furthermore, they also demonstrate that TLR2 has dual immune functions in the gut and identify TLR1 as a critical innate receptor for protective intestinal T(H)17 immunity. The Rockefeller University Press 2012-07-30 /pmc/articles/PMC3409496/ /pubmed/22778390 http://dx.doi.org/10.1084/jem.20112339 Text en © 2012 DePaolo et al. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Brief Definitive Report DePaolo, R. William Kamdar, Karishma Khakpour, Samira Sugiura, Yui Wang, Wenxia Jabri, Bana A specific role for TLR1 in protective T(H)17 immunity during mucosal infection |
title | A specific role for TLR1 in protective T(H)17 immunity during mucosal infection |
title_full | A specific role for TLR1 in protective T(H)17 immunity during mucosal infection |
title_fullStr | A specific role for TLR1 in protective T(H)17 immunity during mucosal infection |
title_full_unstemmed | A specific role for TLR1 in protective T(H)17 immunity during mucosal infection |
title_short | A specific role for TLR1 in protective T(H)17 immunity during mucosal infection |
title_sort | specific role for tlr1 in protective t(h)17 immunity during mucosal infection |
topic | Brief Definitive Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409496/ https://www.ncbi.nlm.nih.gov/pubmed/22778390 http://dx.doi.org/10.1084/jem.20112339 |
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