Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity

Ribonucleases H (RNases H) are endonucleases which cleave the RNA moiety of RNA/DNA hybrids. Their function in mammalian cells is incompletely understood. RNase H2 mutations cause Aicardi-Goutières syndrome, an inflammatory condition clinically overlapping with lupus erythematosus. We show that RNas...

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Detalles Bibliográficos
Autores principales: Hiller, Bjoern, Achleitner, Martin, Glage, Silke, Naumann, Ronald, Behrendt, Rayk, Roers, Axel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409502/
https://www.ncbi.nlm.nih.gov/pubmed/22802351
http://dx.doi.org/10.1084/jem.20120876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409502/
https://www.ncbi.nlm.nih.gov/pubmed/22802351
http://dx.doi.org/10.1084/jem.20120876

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