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Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer
The propensity of colon cancer to metastasize to bones is very low compared to prostate, breast or lung cancer. The reason for this is not yet understood, although an explanation for the osteotropism of certain primaries has been offered by the ‘seed and soil’ concept, suggesting that the bone micro...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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S. Karger AG
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409512/ https://www.ncbi.nlm.nih.gov/pubmed/23525126 http://dx.doi.org/10.1159/000340011 |
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author | Gharwan, Helen Yarlagadda, Lavanya Duffy, Austin |
author_facet | Gharwan, Helen Yarlagadda, Lavanya Duffy, Austin |
author_sort | Gharwan, Helen |
collection | PubMed |
description | The propensity of colon cancer to metastasize to bones is very low compared to prostate, breast or lung cancer. The reason for this is not yet understood, although an explanation for the osteotropism of certain primaries has been offered by the ‘seed and soil’ concept, suggesting that the bone microenvironment provides a favorable ‘soil’ for metastasis and proliferation of some tumor cells (‘seeds’) [1]. Here, we report an unusual case of colon cancer with metastasis to the finger at initial presentation, and exophytic sclerotic lesions to other bones. The incidence of metastases to fingers/toes (acrometastases) is reported to be only 0.1%, even after including involvement of primary sites other than the colon. The etiology and characteristics of acrometastases are reviewed in this case report. |
format | Online Article Text |
id | pubmed-3409512 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-34095122013-03-22 Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer Gharwan, Helen Yarlagadda, Lavanya Duffy, Austin Case Rep Oncol Published online: July, 2012 The propensity of colon cancer to metastasize to bones is very low compared to prostate, breast or lung cancer. The reason for this is not yet understood, although an explanation for the osteotropism of certain primaries has been offered by the ‘seed and soil’ concept, suggesting that the bone microenvironment provides a favorable ‘soil’ for metastasis and proliferation of some tumor cells (‘seeds’) [1]. Here, we report an unusual case of colon cancer with metastasis to the finger at initial presentation, and exophytic sclerotic lesions to other bones. The incidence of metastases to fingers/toes (acrometastases) is reported to be only 0.1%, even after including involvement of primary sites other than the colon. The etiology and characteristics of acrometastases are reviewed in this case report. S. Karger AG 2012-07-26 /pmc/articles/PMC3409512/ /pubmed/23525126 http://dx.doi.org/10.1159/000340011 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published online: July, 2012 Gharwan, Helen Yarlagadda, Lavanya Duffy, Austin Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer |
title | Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer |
title_full | Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer |
title_fullStr | Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer |
title_full_unstemmed | Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer |
title_short | Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer |
title_sort | acrometastasis as the initial presentation of a kras-positive colon cancer |
topic | Published online: July, 2012 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409512/ https://www.ncbi.nlm.nih.gov/pubmed/23525126 http://dx.doi.org/10.1159/000340011 |
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