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Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer

The propensity of colon cancer to metastasize to bones is very low compared to prostate, breast or lung cancer. The reason for this is not yet understood, although an explanation for the osteotropism of certain primaries has been offered by the ‘seed and soil’ concept, suggesting that the bone micro...

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Autores principales: Gharwan, Helen, Yarlagadda, Lavanya, Duffy, Austin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409512/
https://www.ncbi.nlm.nih.gov/pubmed/23525126
http://dx.doi.org/10.1159/000340011
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author Gharwan, Helen
Yarlagadda, Lavanya
Duffy, Austin
author_facet Gharwan, Helen
Yarlagadda, Lavanya
Duffy, Austin
author_sort Gharwan, Helen
collection PubMed
description The propensity of colon cancer to metastasize to bones is very low compared to prostate, breast or lung cancer. The reason for this is not yet understood, although an explanation for the osteotropism of certain primaries has been offered by the ‘seed and soil’ concept, suggesting that the bone microenvironment provides a favorable ‘soil’ for metastasis and proliferation of some tumor cells (‘seeds’) [1]. Here, we report an unusual case of colon cancer with metastasis to the finger at initial presentation, and exophytic sclerotic lesions to other bones. The incidence of metastases to fingers/toes (acrometastases) is reported to be only 0.1%, even after including involvement of primary sites other than the colon. The etiology and characteristics of acrometastases are reviewed in this case report.
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spelling pubmed-34095122013-03-22 Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer Gharwan, Helen Yarlagadda, Lavanya Duffy, Austin Case Rep Oncol Published online: July, 2012 The propensity of colon cancer to metastasize to bones is very low compared to prostate, breast or lung cancer. The reason for this is not yet understood, although an explanation for the osteotropism of certain primaries has been offered by the ‘seed and soil’ concept, suggesting that the bone microenvironment provides a favorable ‘soil’ for metastasis and proliferation of some tumor cells (‘seeds’) [1]. Here, we report an unusual case of colon cancer with metastasis to the finger at initial presentation, and exophytic sclerotic lesions to other bones. The incidence of metastases to fingers/toes (acrometastases) is reported to be only 0.1%, even after including involvement of primary sites other than the colon. The etiology and characteristics of acrometastases are reviewed in this case report. S. Karger AG 2012-07-26 /pmc/articles/PMC3409512/ /pubmed/23525126 http://dx.doi.org/10.1159/000340011 Text en Copyright © 2012 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: July, 2012
Gharwan, Helen
Yarlagadda, Lavanya
Duffy, Austin
Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer
title Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer
title_full Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer
title_fullStr Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer
title_full_unstemmed Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer
title_short Acrometastasis as the Initial Presentation of a KRAS-Positive Colon Cancer
title_sort acrometastasis as the initial presentation of a kras-positive colon cancer
topic Published online: July, 2012
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409512/
https://www.ncbi.nlm.nih.gov/pubmed/23525126
http://dx.doi.org/10.1159/000340011
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