Keratin Expression in Mammary Paget's Disease in situ with Intraductal Invasion

We performed immunohistochemical studies of epithelial keratins in intraductal carcinoma in situ (IDCIS) in mammary Paget's disease (MPD). K7, K8 and K18 were expressed in IDCIS in MPD. However, K19 was not expressed in IDCIS in MPD. Interestingly, K17 was expressed in some tumor cells in IDCIS...

Descripción completa

Detalles Bibliográficos
Autores principales: Kurokawa, Ichiro, Furukawa, Sayaka, Kishimoto, Masahiro, Kakuno, Ayako, Tsubura, Airo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2012
Materias:
Published online: July, 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409513/
https://www.ncbi.nlm.nih.gov/pubmed/23525171
http://dx.doi.org/10.1159/000341663
Descripción
Sumario:We performed immunohistochemical studies of epithelial keratins in intraductal carcinoma in situ (IDCIS) in mammary Paget's disease (MPD). K7, K8 and K18 were expressed in IDCIS in MPD. However, K19 was not expressed in IDCIS in MPD. Interestingly, K17 was expressed in some tumor cells in IDCIS. K17, a hyperproliferative keratin, may suggest ductal invasion and poor prognosis in MPD.

Ejemplares similares