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Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation

Vascular inflammation plays a crucial role in atherosclerosis, and its regulation is important to prevent cerebrovascular and coronary artery disease. The inflammatory process in atherogenesis involves a variety of immune cells including monocytes/macrophages, lymphocytes, dendritic cells, and neutr...

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Detalles Bibliográficos
Autores principales: Ohshima, Kousei, Mogi, Masaki, Horiuchi, Masatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409528/
https://www.ncbi.nlm.nih.gov/pubmed/22888436
http://dx.doi.org/10.1155/2012/508416
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author Ohshima, Kousei
Mogi, Masaki
Horiuchi, Masatsugu
author_facet Ohshima, Kousei
Mogi, Masaki
Horiuchi, Masatsugu
author_sort Ohshima, Kousei
collection PubMed
description Vascular inflammation plays a crucial role in atherosclerosis, and its regulation is important to prevent cerebrovascular and coronary artery disease. The inflammatory process in atherogenesis involves a variety of immune cells including monocytes/macrophages, lymphocytes, dendritic cells, and neutrophils, which all express peroxisome proliferator-activated receptor-γ (PPAR-γ). PPAR-γ is a nuclear receptor and transcription factor in the steroid superfamily and is known to be a key regulator of adipocyte differentiation. Increasing evidence from mainly experimental studies has demonstrated that PPAR-γ activation by endogenous and synthetic ligands is involved in lipid metabolism and anti-inflammatory activity. In addition, recent clinical studies have shown a beneficial effect of thiazolidinediones, synthetic PPAR-γ ligands, on cardiovascular disease beyond glycemic control. These results suggest that PPAR-γ activation is an important regulator in vascular inflammation and is expected to be a therapeutic target in the treatment of atherosclerotic complications. This paper reviews the recent findings of PPAR-γ involvement in vascular inflammation and the therapeutic potential of regulating the immune system in atherosclerosis.
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spelling pubmed-34095282012-08-10 Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation Ohshima, Kousei Mogi, Masaki Horiuchi, Masatsugu Int J Vasc Med Review Article Vascular inflammation plays a crucial role in atherosclerosis, and its regulation is important to prevent cerebrovascular and coronary artery disease. The inflammatory process in atherogenesis involves a variety of immune cells including monocytes/macrophages, lymphocytes, dendritic cells, and neutrophils, which all express peroxisome proliferator-activated receptor-γ (PPAR-γ). PPAR-γ is a nuclear receptor and transcription factor in the steroid superfamily and is known to be a key regulator of adipocyte differentiation. Increasing evidence from mainly experimental studies has demonstrated that PPAR-γ activation by endogenous and synthetic ligands is involved in lipid metabolism and anti-inflammatory activity. In addition, recent clinical studies have shown a beneficial effect of thiazolidinediones, synthetic PPAR-γ ligands, on cardiovascular disease beyond glycemic control. These results suggest that PPAR-γ activation is an important regulator in vascular inflammation and is expected to be a therapeutic target in the treatment of atherosclerotic complications. This paper reviews the recent findings of PPAR-γ involvement in vascular inflammation and the therapeutic potential of regulating the immune system in atherosclerosis. Hindawi Publishing Corporation 2012 2012-07-24 /pmc/articles/PMC3409528/ /pubmed/22888436 http://dx.doi.org/10.1155/2012/508416 Text en Copyright © 2012 Kousei Ohshima et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ohshima, Kousei
Mogi, Masaki
Horiuchi, Masatsugu
Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation
title Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation
title_full Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation
title_fullStr Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation
title_full_unstemmed Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation
title_short Role of Peroxisome Proliferator-Activated Receptor-γ in Vascular Inflammation
title_sort role of peroxisome proliferator-activated receptor-γ in vascular inflammation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409528/
https://www.ncbi.nlm.nih.gov/pubmed/22888436
http://dx.doi.org/10.1155/2012/508416
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