DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities

Werner protein (WRN), member of the RecQ helicase family, is a helicase and exonuclease, and participates in multiple DNA metabolic processes including DNA replication, recombination and DNA repair. Mutations in the WRN gene cause Werner syndrome, associated with premature aging, genome instability...

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Detalles Bibliográficos
Autores principales: Tadokoro, Takashi, Kulikowicz, Tomasz, Dawut, Lale, Croteau, Deborah L., Bohr, Vilhelm A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3409678/
https://www.ncbi.nlm.nih.gov/pubmed/22713343

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