Cargando…

Molecular basis of the structure and function of H1 hemagglutinin of influenza virus

Influenza virus hemagglutinin (HA) contains antigenic sites recognized by the host immune system, cleavage sites cleaved by host proteases, receptor binding sites attaching to sialyl receptors on the target cell, and fusion peptides mediating membrane fusion. Change in an amino acid(s) in these site...

Descripción completa

Detalles Bibliográficos
Autores principales: SRIWILAIJAROEN, Nongluk, SUZUKI, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410141/
https://www.ncbi.nlm.nih.gov/pubmed/22728439
http://dx.doi.org/10.2183/pjab.88.226
_version_ 1782239685107515392
author SRIWILAIJAROEN, Nongluk
SUZUKI, Yasuo
author_facet SRIWILAIJAROEN, Nongluk
SUZUKI, Yasuo
author_sort SRIWILAIJAROEN, Nongluk
collection PubMed
description Influenza virus hemagglutinin (HA) contains antigenic sites recognized by the host immune system, cleavage sites cleaved by host proteases, receptor binding sites attaching to sialyl receptors on the target cell, and fusion peptides mediating membrane fusion. Change in an amino acid(s) in these sites may affect the potential of virus infection and spread within and between hosts. Influenza viruses with H1 HA infect birds, pigs and humans and have caused two of the four pandemics in the past 100 years: 1918 pandemic that killed 21–50 million people(1)) and 2009 pandemic that caused more than 18,000 deaths.(2)) Understanding the relationship between antigenic structure and immune specificity, the receptor binding specificity in virus transmission, how the cleavage site controls pathogenicity, and how the fusion peptide causes membrane fusion for the entry of influenza virus into the host cell should provide information to find more effective ways to prevent and control influenza.
format Online
Article
Text
id pubmed-3410141
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher The Japan Academy
record_format MEDLINE/PubMed
spelling pubmed-34101412012-08-20 Molecular basis of the structure and function of H1 hemagglutinin of influenza virus SRIWILAIJAROEN, Nongluk SUZUKI, Yasuo Proc Jpn Acad Ser B Phys Biol Sci Review Influenza virus hemagglutinin (HA) contains antigenic sites recognized by the host immune system, cleavage sites cleaved by host proteases, receptor binding sites attaching to sialyl receptors on the target cell, and fusion peptides mediating membrane fusion. Change in an amino acid(s) in these sites may affect the potential of virus infection and spread within and between hosts. Influenza viruses with H1 HA infect birds, pigs and humans and have caused two of the four pandemics in the past 100 years: 1918 pandemic that killed 21–50 million people(1)) and 2009 pandemic that caused more than 18,000 deaths.(2)) Understanding the relationship between antigenic structure and immune specificity, the receptor binding specificity in virus transmission, how the cleavage site controls pathogenicity, and how the fusion peptide causes membrane fusion for the entry of influenza virus into the host cell should provide information to find more effective ways to prevent and control influenza. The Japan Academy 2012-06-11 /pmc/articles/PMC3410141/ /pubmed/22728439 http://dx.doi.org/10.2183/pjab.88.226 Text en © 2012 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
SRIWILAIJAROEN, Nongluk
SUZUKI, Yasuo
Molecular basis of the structure and function of H1 hemagglutinin of influenza virus
title Molecular basis of the structure and function of H1 hemagglutinin of influenza virus
title_full Molecular basis of the structure and function of H1 hemagglutinin of influenza virus
title_fullStr Molecular basis of the structure and function of H1 hemagglutinin of influenza virus
title_full_unstemmed Molecular basis of the structure and function of H1 hemagglutinin of influenza virus
title_short Molecular basis of the structure and function of H1 hemagglutinin of influenza virus
title_sort molecular basis of the structure and function of h1 hemagglutinin of influenza virus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410141/
https://www.ncbi.nlm.nih.gov/pubmed/22728439
http://dx.doi.org/10.2183/pjab.88.226
work_keys_str_mv AT sriwilaijaroennongluk molecularbasisofthestructureandfunctionofh1hemagglutininofinfluenzavirus
AT suzukiyasuo molecularbasisofthestructureandfunctionofh1hemagglutininofinfluenzavirus