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Mycobacterial Pulmonary Infections in Patients with Idiopathic Pulmonary Fibrosis

Patients with idiopathic pulmonary fibrosis (IPF) have an increased risk for developing tuberculosis (TB). However, no studies have been reported regarding the development of nontuberculous mycobacterium (NTM) lung disease (NTMLD). We reviewed 795 patients with IPF from five university hospitals who...

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Autores principales: Park, Sung-Woo, Song, Jin Woo, Shim, Tae Sun, Park, Moo-Suk, Lee, Hong-Lyeol, Uh, Soo-Taek, Park, Choon-Sik, Kim, Dong Soon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410237/
https://www.ncbi.nlm.nih.gov/pubmed/22876056
http://dx.doi.org/10.3346/jkms.2012.27.8.896
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author Park, Sung-Woo
Song, Jin Woo
Shim, Tae Sun
Park, Moo-Suk
Lee, Hong-Lyeol
Uh, Soo-Taek
Park, Choon-Sik
Kim, Dong Soon
author_facet Park, Sung-Woo
Song, Jin Woo
Shim, Tae Sun
Park, Moo-Suk
Lee, Hong-Lyeol
Uh, Soo-Taek
Park, Choon-Sik
Kim, Dong Soon
author_sort Park, Sung-Woo
collection PubMed
description Patients with idiopathic pulmonary fibrosis (IPF) have an increased risk for developing tuberculosis (TB). However, no studies have been reported regarding the development of nontuberculous mycobacterium (NTM) lung disease (NTMLD). We reviewed 795 patients with IPF from five university hospitals who were diagnosed by histological or radio-clinical criteria. In the 795 patients with IPF, pulmonary infections with mycobacterium tuberculosis (MTB) and NTM were found in 35 (4.4%) and 16 patients (2.0%), respectively, which was a higher frequency than that found in the general population. TB was more common in patients treated with immunosuppressants than in those who did not receive immunosuppressants (2.6% vs 1.4%, P = 0.12). Among the IPF patients who had mycobacterial infections,immunosuppressant users developed TB or NTMLD within 1 yr after treatment with immunosuppressants,while those occurred later than 2 yr after diagnosis of IPF in the subjects that did not receive immunosuppressants. Among 51 IPF patients who had mycobacterial infections, 9 (18%) died during follow-up. Of these, three died due to progression of pulmonary tuberculosis. TB and NTMLD is relatively common in patients with IPF in Korea and may be fatal in some groups. Careful evaluation of TB and NTMLD is necessary not only for immunosuppressant users, but also for nonusers with IPF.
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spelling pubmed-34102372012-08-08 Mycobacterial Pulmonary Infections in Patients with Idiopathic Pulmonary Fibrosis Park, Sung-Woo Song, Jin Woo Shim, Tae Sun Park, Moo-Suk Lee, Hong-Lyeol Uh, Soo-Taek Park, Choon-Sik Kim, Dong Soon J Korean Med Sci Original Article Patients with idiopathic pulmonary fibrosis (IPF) have an increased risk for developing tuberculosis (TB). However, no studies have been reported regarding the development of nontuberculous mycobacterium (NTM) lung disease (NTMLD). We reviewed 795 patients with IPF from five university hospitals who were diagnosed by histological or radio-clinical criteria. In the 795 patients with IPF, pulmonary infections with mycobacterium tuberculosis (MTB) and NTM were found in 35 (4.4%) and 16 patients (2.0%), respectively, which was a higher frequency than that found in the general population. TB was more common in patients treated with immunosuppressants than in those who did not receive immunosuppressants (2.6% vs 1.4%, P = 0.12). Among the IPF patients who had mycobacterial infections,immunosuppressant users developed TB or NTMLD within 1 yr after treatment with immunosuppressants,while those occurred later than 2 yr after diagnosis of IPF in the subjects that did not receive immunosuppressants. Among 51 IPF patients who had mycobacterial infections, 9 (18%) died during follow-up. Of these, three died due to progression of pulmonary tuberculosis. TB and NTMLD is relatively common in patients with IPF in Korea and may be fatal in some groups. Careful evaluation of TB and NTMLD is necessary not only for immunosuppressant users, but also for nonusers with IPF. The Korean Academy of Medical Sciences 2012-08 2012-07-25 /pmc/articles/PMC3410237/ /pubmed/22876056 http://dx.doi.org/10.3346/jkms.2012.27.8.896 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Sung-Woo
Song, Jin Woo
Shim, Tae Sun
Park, Moo-Suk
Lee, Hong-Lyeol
Uh, Soo-Taek
Park, Choon-Sik
Kim, Dong Soon
Mycobacterial Pulmonary Infections in Patients with Idiopathic Pulmonary Fibrosis
title Mycobacterial Pulmonary Infections in Patients with Idiopathic Pulmonary Fibrosis
title_full Mycobacterial Pulmonary Infections in Patients with Idiopathic Pulmonary Fibrosis
title_fullStr Mycobacterial Pulmonary Infections in Patients with Idiopathic Pulmonary Fibrosis
title_full_unstemmed Mycobacterial Pulmonary Infections in Patients with Idiopathic Pulmonary Fibrosis
title_short Mycobacterial Pulmonary Infections in Patients with Idiopathic Pulmonary Fibrosis
title_sort mycobacterial pulmonary infections in patients with idiopathic pulmonary fibrosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410237/
https://www.ncbi.nlm.nih.gov/pubmed/22876056
http://dx.doi.org/10.3346/jkms.2012.27.8.896
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