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Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models
Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors. Understanding the genetic controls of hematopoiesis is crucial...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410305/ https://www.ncbi.nlm.nih.gov/pubmed/22888355 http://dx.doi.org/10.1155/2012/830703 |
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author | Sood, Raman Liu, Paul |
author_facet | Sood, Raman Liu, Paul |
author_sort | Sood, Raman |
collection | PubMed |
description | Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors. Understanding the genetic controls of hematopoiesis is crucial as perturbations in hematopoiesis lead to diseases such as anemia, thrombocytopenia, or cancers, including leukemias and lymphomas. Animal models, particularly conventional and conditional knockout mice, have played major roles in our understanding of the genetic controls of hematopoiesis. However, knockout mice for most of the hematopoietic transcription factors are embryonic lethal, thus precluding the analysis of their roles during the transition from embryonic to adult hematopoiesis. Zebrafish are an ideal model organism to determine the function of a gene during embryonic-to-adult transition of hematopoiesis since bloodless zebrafish embryos can develop normally into early larval stage by obtaining oxygen through diffusion. In this review, we discuss the current status of the ontogeny and regulation of hematopoiesis in zebrafish. By providing specific examples of zebrafish morphants and mutants, we have highlighted the contributions of the zebrafish model to our overall understanding of the roles of transcription factors in regulation of primitive and definitive hematopoiesis. |
format | Online Article Text |
id | pubmed-3410305 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34103052012-08-10 Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models Sood, Raman Liu, Paul Adv Hematol Review Article Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors. Understanding the genetic controls of hematopoiesis is crucial as perturbations in hematopoiesis lead to diseases such as anemia, thrombocytopenia, or cancers, including leukemias and lymphomas. Animal models, particularly conventional and conditional knockout mice, have played major roles in our understanding of the genetic controls of hematopoiesis. However, knockout mice for most of the hematopoietic transcription factors are embryonic lethal, thus precluding the analysis of their roles during the transition from embryonic to adult hematopoiesis. Zebrafish are an ideal model organism to determine the function of a gene during embryonic-to-adult transition of hematopoiesis since bloodless zebrafish embryos can develop normally into early larval stage by obtaining oxygen through diffusion. In this review, we discuss the current status of the ontogeny and regulation of hematopoiesis in zebrafish. By providing specific examples of zebrafish morphants and mutants, we have highlighted the contributions of the zebrafish model to our overall understanding of the roles of transcription factors in regulation of primitive and definitive hematopoiesis. Hindawi Publishing Corporation 2012 2012-07-25 /pmc/articles/PMC3410305/ /pubmed/22888355 http://dx.doi.org/10.1155/2012/830703 Text en Copyright © 2012 R. Sood and P. Liu. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sood, Raman Liu, Paul Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models |
title | Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models |
title_full | Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models |
title_fullStr | Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models |
title_full_unstemmed | Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models |
title_short | Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models |
title_sort | novel insights into the genetic controls of primitive and definitive hematopoiesis from zebrafish models |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410305/ https://www.ncbi.nlm.nih.gov/pubmed/22888355 http://dx.doi.org/10.1155/2012/830703 |
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