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Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models

Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors. Understanding the genetic controls of hematopoiesis is crucial...

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Detalles Bibliográficos
Autores principales: Sood, Raman, Liu, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410305/
https://www.ncbi.nlm.nih.gov/pubmed/22888355
http://dx.doi.org/10.1155/2012/830703
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author Sood, Raman
Liu, Paul
author_facet Sood, Raman
Liu, Paul
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description Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors. Understanding the genetic controls of hematopoiesis is crucial as perturbations in hematopoiesis lead to diseases such as anemia, thrombocytopenia, or cancers, including leukemias and lymphomas. Animal models, particularly conventional and conditional knockout mice, have played major roles in our understanding of the genetic controls of hematopoiesis. However, knockout mice for most of the hematopoietic transcription factors are embryonic lethal, thus precluding the analysis of their roles during the transition from embryonic to adult hematopoiesis. Zebrafish are an ideal model organism to determine the function of a gene during embryonic-to-adult transition of hematopoiesis since bloodless zebrafish embryos can develop normally into early larval stage by obtaining oxygen through diffusion. In this review, we discuss the current status of the ontogeny and regulation of hematopoiesis in zebrafish. By providing specific examples of zebrafish morphants and mutants, we have highlighted the contributions of the zebrafish model to our overall understanding of the roles of transcription factors in regulation of primitive and definitive hematopoiesis.
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spelling pubmed-34103052012-08-10 Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models Sood, Raman Liu, Paul Adv Hematol Review Article Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors. Understanding the genetic controls of hematopoiesis is crucial as perturbations in hematopoiesis lead to diseases such as anemia, thrombocytopenia, or cancers, including leukemias and lymphomas. Animal models, particularly conventional and conditional knockout mice, have played major roles in our understanding of the genetic controls of hematopoiesis. However, knockout mice for most of the hematopoietic transcription factors are embryonic lethal, thus precluding the analysis of their roles during the transition from embryonic to adult hematopoiesis. Zebrafish are an ideal model organism to determine the function of a gene during embryonic-to-adult transition of hematopoiesis since bloodless zebrafish embryos can develop normally into early larval stage by obtaining oxygen through diffusion. In this review, we discuss the current status of the ontogeny and regulation of hematopoiesis in zebrafish. By providing specific examples of zebrafish morphants and mutants, we have highlighted the contributions of the zebrafish model to our overall understanding of the roles of transcription factors in regulation of primitive and definitive hematopoiesis. Hindawi Publishing Corporation 2012 2012-07-25 /pmc/articles/PMC3410305/ /pubmed/22888355 http://dx.doi.org/10.1155/2012/830703 Text en Copyright © 2012 R. Sood and P. Liu. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sood, Raman
Liu, Paul
Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models
title Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models
title_full Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models
title_fullStr Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models
title_full_unstemmed Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models
title_short Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models
title_sort novel insights into the genetic controls of primitive and definitive hematopoiesis from zebrafish models
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410305/
https://www.ncbi.nlm.nih.gov/pubmed/22888355
http://dx.doi.org/10.1155/2012/830703
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