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Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography

Background. Optical coherence tomography (OCT) has facilitated characterisation of retinal alterations in MS patients. Only scarce and in part conflicting data exists on different MS subtypes. Objective. To analyse patterns of retinal changes in different subtypes of MS with latest spectral-domain t...

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Autores principales: Oberwahrenbrock, Timm, Schippling, Sven, Ringelstein, Marius, Kaufhold, Falko, Zimmermann, Hanna, Keser, Nazmiye, Young, Kim Lea, Harmel, Jens, Hartung, Hans-Peter, Martin, Roland, Paul, Friedemann, Aktas, Orhan, Brandt, Alexander U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410317/
https://www.ncbi.nlm.nih.gov/pubmed/22888431
http://dx.doi.org/10.1155/2012/530305
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author Oberwahrenbrock, Timm
Schippling, Sven
Ringelstein, Marius
Kaufhold, Falko
Zimmermann, Hanna
Keser, Nazmiye
Young, Kim Lea
Harmel, Jens
Hartung, Hans-Peter
Martin, Roland
Paul, Friedemann
Aktas, Orhan
Brandt, Alexander U.
author_facet Oberwahrenbrock, Timm
Schippling, Sven
Ringelstein, Marius
Kaufhold, Falko
Zimmermann, Hanna
Keser, Nazmiye
Young, Kim Lea
Harmel, Jens
Hartung, Hans-Peter
Martin, Roland
Paul, Friedemann
Aktas, Orhan
Brandt, Alexander U.
author_sort Oberwahrenbrock, Timm
collection PubMed
description Background. Optical coherence tomography (OCT) has facilitated characterisation of retinal alterations in MS patients. Only scarce and in part conflicting data exists on different MS subtypes. Objective. To analyse patterns of retinal changes in different subtypes of MS with latest spectral-domain technology. Methods. In a three-centre cross-sectional study 414 MS patients and 94 healthy controls underwent spectral-domain OCT examination. Results. Eyes of MS patients without a previous optic neuritis showed a significant reduction of both retinal nerve fibre layer (RNFL) thickness and total macular volume (TMV) compared to healthy controls independent of the MS subtype (P < 0.001 for all subtypes). RNFL thickness was lower in secondary progressive MS (SPMS) eyes compared to relapsing-remitting MS (RRMS) eyes (P = 0.007), and TMV was reduced in SPMS and primary progressive MS (PPMS) eyes compared to RRMS eyes (SPMS: P = 0.039, PPMS: P = 0.005). Independent of the subtype a more pronounced RNFL thinning and TMV reduction were found in eyes with a previous optic neuritis compared to unaffected eyes. Conclusion. Analysis of this large-scale cross-sectional dataset of MS patients studied with spectral-domain OCT confirmed and allows to generalize previous findings. Furthermore it carves out distinct patterns in different MS subtypes.
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spelling pubmed-34103172012-08-10 Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography Oberwahrenbrock, Timm Schippling, Sven Ringelstein, Marius Kaufhold, Falko Zimmermann, Hanna Keser, Nazmiye Young, Kim Lea Harmel, Jens Hartung, Hans-Peter Martin, Roland Paul, Friedemann Aktas, Orhan Brandt, Alexander U. Mult Scler Int Clinical Study Background. Optical coherence tomography (OCT) has facilitated characterisation of retinal alterations in MS patients. Only scarce and in part conflicting data exists on different MS subtypes. Objective. To analyse patterns of retinal changes in different subtypes of MS with latest spectral-domain technology. Methods. In a three-centre cross-sectional study 414 MS patients and 94 healthy controls underwent spectral-domain OCT examination. Results. Eyes of MS patients without a previous optic neuritis showed a significant reduction of both retinal nerve fibre layer (RNFL) thickness and total macular volume (TMV) compared to healthy controls independent of the MS subtype (P < 0.001 for all subtypes). RNFL thickness was lower in secondary progressive MS (SPMS) eyes compared to relapsing-remitting MS (RRMS) eyes (P = 0.007), and TMV was reduced in SPMS and primary progressive MS (PPMS) eyes compared to RRMS eyes (SPMS: P = 0.039, PPMS: P = 0.005). Independent of the subtype a more pronounced RNFL thinning and TMV reduction were found in eyes with a previous optic neuritis compared to unaffected eyes. Conclusion. Analysis of this large-scale cross-sectional dataset of MS patients studied with spectral-domain OCT confirmed and allows to generalize previous findings. Furthermore it carves out distinct patterns in different MS subtypes. Hindawi Publishing Corporation 2012 2012-07-25 /pmc/articles/PMC3410317/ /pubmed/22888431 http://dx.doi.org/10.1155/2012/530305 Text en Copyright © 2012 Timm Oberwahrenbrock et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Oberwahrenbrock, Timm
Schippling, Sven
Ringelstein, Marius
Kaufhold, Falko
Zimmermann, Hanna
Keser, Nazmiye
Young, Kim Lea
Harmel, Jens
Hartung, Hans-Peter
Martin, Roland
Paul, Friedemann
Aktas, Orhan
Brandt, Alexander U.
Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography
title Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography
title_full Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography
title_fullStr Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography
title_full_unstemmed Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography
title_short Retinal Damage in Multiple Sclerosis Disease Subtypes Measured by High-Resolution Optical Coherence Tomography
title_sort retinal damage in multiple sclerosis disease subtypes measured by high-resolution optical coherence tomography
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410317/
https://www.ncbi.nlm.nih.gov/pubmed/22888431
http://dx.doi.org/10.1155/2012/530305
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