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K-Ras and B-Raf oncogenes inhibit colon epithelial polarity establishment through up-regulation of c-myc

KRAS, BRAF, and PI3KCA are the most frequently mutated oncogenes in human colon cancer. To explore their effects on morphogenesis, we used the colon cancer–derived cell line Caco-2. When seeded in extracellular matrix, individual cells proliferate and generate hollow, polarized cysts. The expression...

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Detalles Bibliográficos
Autores principales:	Magudia, Kirti, Lahoz, Aurelia, Hall, Alan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410422/ https://www.ncbi.nlm.nih.gov/pubmed/22826122 http://dx.doi.org/10.1083/jcb.201202108

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