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Dendritic cells a double-edge sword in autoimmune responses
Dendritic cells (DC) are antigen-presenting cells that play a pivotal role in regulating innate and adaptive immune responses. In autoimmunity, DC act as a double-edged sword since on one hand they initiate adaptive self-reactive responses and on the other they play a pivotal role in promoting and m...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410601/ https://www.ncbi.nlm.nih.gov/pubmed/22876246 http://dx.doi.org/10.3389/fimmu.2012.00233 |
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author | Amodio, Giada Gregori, Silvia |
author_facet | Amodio, Giada Gregori, Silvia |
author_sort | Amodio, Giada |
collection | PubMed |
description | Dendritic cells (DC) are antigen-presenting cells that play a pivotal role in regulating innate and adaptive immune responses. In autoimmunity, DC act as a double-edged sword since on one hand they initiate adaptive self-reactive responses and on the other they play a pivotal role in promoting and maintaining tolerance. Thus, DC are the most important cells in either triggering self-specific responses or in negatively regulating auto-reactive responses. The latter function is mediated by DC in the steady-state or specialized subsets of DC, named tolerogenic DC. Clinical and experimental evidence indicate that prolonged presentation of self-antigens by DC is crucial for the development of destructive autoimmune diseases, and defects in tolerogenic DC functions contribute to eradication of self-tolerance. In recent years, DC have emerged as therapeutic targets for limiting their immunogenicity against self-antigens, while tolerogenic DC have been conceived as therapeutic tools to restore tolerance. The purpose of this review is to give a general overview of the current knowledge on the pathogenic role of DC in patients affected by autoimmune diseases. In addition, the protective role of tolerogenic DC will be addressed. The currently applied strategies to block immune activation or to exploit the tolerogenic potential of DC will be discussed. |
format | Online Article Text |
id | pubmed-3410601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34106012012-08-08 Dendritic cells a double-edge sword in autoimmune responses Amodio, Giada Gregori, Silvia Front Immunol Immunology Dendritic cells (DC) are antigen-presenting cells that play a pivotal role in regulating innate and adaptive immune responses. In autoimmunity, DC act as a double-edged sword since on one hand they initiate adaptive self-reactive responses and on the other they play a pivotal role in promoting and maintaining tolerance. Thus, DC are the most important cells in either triggering self-specific responses or in negatively regulating auto-reactive responses. The latter function is mediated by DC in the steady-state or specialized subsets of DC, named tolerogenic DC. Clinical and experimental evidence indicate that prolonged presentation of self-antigens by DC is crucial for the development of destructive autoimmune diseases, and defects in tolerogenic DC functions contribute to eradication of self-tolerance. In recent years, DC have emerged as therapeutic targets for limiting their immunogenicity against self-antigens, while tolerogenic DC have been conceived as therapeutic tools to restore tolerance. The purpose of this review is to give a general overview of the current knowledge on the pathogenic role of DC in patients affected by autoimmune diseases. In addition, the protective role of tolerogenic DC will be addressed. The currently applied strategies to block immune activation or to exploit the tolerogenic potential of DC will be discussed. Frontiers Research Foundation 2012-08-02 /pmc/articles/PMC3410601/ /pubmed/22876246 http://dx.doi.org/10.3389/fimmu.2012.00233 Text en Copyright © Amodio and Gregori. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Immunology Amodio, Giada Gregori, Silvia Dendritic cells a double-edge sword in autoimmune responses |
title | Dendritic cells a double-edge sword in autoimmune responses |
title_full | Dendritic cells a double-edge sword in autoimmune responses |
title_fullStr | Dendritic cells a double-edge sword in autoimmune responses |
title_full_unstemmed | Dendritic cells a double-edge sword in autoimmune responses |
title_short | Dendritic cells a double-edge sword in autoimmune responses |
title_sort | dendritic cells a double-edge sword in autoimmune responses |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410601/ https://www.ncbi.nlm.nih.gov/pubmed/22876246 http://dx.doi.org/10.3389/fimmu.2012.00233 |
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