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Endoplasmic reticulum involvement in yeast cell death

Yeast cells undergo programed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation. Though significant research has focused on mitochondrial involv...

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Detalles Bibliográficos
Autor principal: Austriaco, O. P., Nicanor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410633/
https://www.ncbi.nlm.nih.gov/pubmed/22876361
http://dx.doi.org/10.3389/fonc.2012.00087
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author Austriaco, O. P., Nicanor
author_facet Austriaco, O. P., Nicanor
author_sort Austriaco, O. P., Nicanor
collection PubMed
description Yeast cells undergo programed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation. Though significant research has focused on mitochondrial involvement in this phenomenon, more recent work with both Saccharomyces cerevisiae and Schizosaccharomyces pombe has also implicated the endoplasmic reticulum (ER) in yeast PCD. This minireview provides an overview of ER stress-associated cell death (ER-SAD) in yeast. It begins with a description of ER structure and function in yeast before moving to a discussion of ER-SAD in both mammalian and yeast cells. Three examples of yeast cell death associated with the ER will be highlighted here including inositol starvation, lipid toxicity, and the inhibition of N-glycosylation. It closes by suggesting ways to further examine the involvement of the ER in yeast cell death.
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spelling pubmed-34106332012-08-08 Endoplasmic reticulum involvement in yeast cell death Austriaco, O. P., Nicanor Front Oncol Oncology Yeast cells undergo programed cell death (PCD) with characteristic markers associated with apoptosis in mammalian cells including chromatin breakage, nuclear fragmentation, reactive oxygen species generation, and metacaspase activation. Though significant research has focused on mitochondrial involvement in this phenomenon, more recent work with both Saccharomyces cerevisiae and Schizosaccharomyces pombe has also implicated the endoplasmic reticulum (ER) in yeast PCD. This minireview provides an overview of ER stress-associated cell death (ER-SAD) in yeast. It begins with a description of ER structure and function in yeast before moving to a discussion of ER-SAD in both mammalian and yeast cells. Three examples of yeast cell death associated with the ER will be highlighted here including inositol starvation, lipid toxicity, and the inhibition of N-glycosylation. It closes by suggesting ways to further examine the involvement of the ER in yeast cell death. Frontiers Research Foundation 2012-08-02 /pmc/articles/PMC3410633/ /pubmed/22876361 http://dx.doi.org/10.3389/fonc.2012.00087 Text en Copyright © Austriaco. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics, etc.
spellingShingle Oncology
Austriaco, O. P., Nicanor
Endoplasmic reticulum involvement in yeast cell death
title Endoplasmic reticulum involvement in yeast cell death
title_full Endoplasmic reticulum involvement in yeast cell death
title_fullStr Endoplasmic reticulum involvement in yeast cell death
title_full_unstemmed Endoplasmic reticulum involvement in yeast cell death
title_short Endoplasmic reticulum involvement in yeast cell death
title_sort endoplasmic reticulum involvement in yeast cell death
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410633/
https://www.ncbi.nlm.nih.gov/pubmed/22876361
http://dx.doi.org/10.3389/fonc.2012.00087
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