Complexin cross-links pre-fusion SNAREs into a zig-zag array: a structure-based model for complexin clamping

Complexin prevents SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. To understand the mechanism for this inhibition, we determined the structure of complexin bound to a mimetic of a pre-fusion SNAREpin lacking the portion of the v-SNARE which zippers last to...

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Detalles Bibliográficos
Autores principales: Kümmel, Daniel, Krishnakumar, Shyam S., Radoff, Daniel T., Li, Feng, Giraudo, Claudio G., Pincet, Frederic, Rothman, James E., Reinisch, Karin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410656/
https://www.ncbi.nlm.nih.gov/pubmed/21785414
http://dx.doi.org/10.1038/nsmb.2101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410656/
https://www.ncbi.nlm.nih.gov/pubmed/21785414
http://dx.doi.org/10.1038/nsmb.2101

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