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Small Protease Sensitive Oligomers of PrP(Sc) in Distinct Human Prions Determine Conversion Rate of PrP(C)

The mammalian prions replicate by converting cellular prion protein (PrP(C)) into pathogenic conformational isoform (PrP(Sc)). Variations in prions, which cause different disease phenotypes, are referred to as strains. The mechanism of high-fidelity replication of prion strains in the absence of nuc...

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Detalles Bibliográficos
Autores principales:	Kim, Chae, Haldiman, Tracy, Surewicz, Krystyna, Cohen, Yvonne, Chen, Wei, Blevins, Janis, Sy, Man-Sun, Cohen, Mark, Kong, Qingzhong, Telling, Glenn C., Surewicz, Witold K., Safar, Jiri G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410855/ https://www.ncbi.nlm.nih.gov/pubmed/22876179 http://dx.doi.org/10.1371/journal.ppat.1002835

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