Cargando…
The incidence of venous thromboembolism in cervical cancer: a nationwide population-based study
BACKGROUND: Venous thromboembolism (VTE) is a life-threatening condition that occurs as a complication of cervical cancer. The aim of this study was to evaluate the incidence of VTE in cervical cancer patients during a 5-year follow-up. METHODS: The study analyzed data deposited between 2003 and 200...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410881/ https://www.ncbi.nlm.nih.gov/pubmed/22721503 http://dx.doi.org/10.1186/1756-0500-5-316 |
_version_ | 1782239778366816256 |
---|---|
author | Tsai, Shiang-Jiun Ruan, Ying-Xu Lee, Ching-Chih Lee, Moon-Sing Chiou, Wen-Yen Lin, Hon-Yi Hsu, Feng-Chun Su, Yu-Chieh Hung, Shih-Kai |
author_facet | Tsai, Shiang-Jiun Ruan, Ying-Xu Lee, Ching-Chih Lee, Moon-Sing Chiou, Wen-Yen Lin, Hon-Yi Hsu, Feng-Chun Su, Yu-Chieh Hung, Shih-Kai |
author_sort | Tsai, Shiang-Jiun |
collection | PubMed |
description | BACKGROUND: Venous thromboembolism (VTE) is a life-threatening condition that occurs as a complication of cervical cancer. The aim of this study was to evaluate the incidence of VTE in cervical cancer patients during a 5-year follow-up. METHODS: The study analyzed data deposited between 2003 and 2008 in the National Health Insurance Research Database (NHIRD), provided by the National Health Research Institutes in Taiwan. Totally, 1013 cervical cancer patients after treatment and 2026 appendectomy patients were eligible. The Kaplan-Meier method and the Cox proportional hazards model were used to assess the VTE risk. RESULTS: The 5-year cumulative risk for VTE was significantly higher in the cervical cancer group than in the control group (3.3% vs 0.3%, p < 0.001). The hazard ratio for VTE was 10.14 times higher in the cervical cancer group than in the controls. The combined presence of more comorbidities was associated with a higher risk for VTE. Furthermore, cervical cancer patients without VTE had a significantly higher survival (75.3% vs 30.3%, p < 0.001). CONCLUSIONS: The cumulative risk of VTE was significantly higher in cervical cancer patients, and these patients also had lower survival rates. Strategies to reduce these risks need to be examined. |
format | Online Article Text |
id | pubmed-3410881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34108812012-08-03 The incidence of venous thromboembolism in cervical cancer: a nationwide population-based study Tsai, Shiang-Jiun Ruan, Ying-Xu Lee, Ching-Chih Lee, Moon-Sing Chiou, Wen-Yen Lin, Hon-Yi Hsu, Feng-Chun Su, Yu-Chieh Hung, Shih-Kai BMC Res Notes Research Article BACKGROUND: Venous thromboembolism (VTE) is a life-threatening condition that occurs as a complication of cervical cancer. The aim of this study was to evaluate the incidence of VTE in cervical cancer patients during a 5-year follow-up. METHODS: The study analyzed data deposited between 2003 and 2008 in the National Health Insurance Research Database (NHIRD), provided by the National Health Research Institutes in Taiwan. Totally, 1013 cervical cancer patients after treatment and 2026 appendectomy patients were eligible. The Kaplan-Meier method and the Cox proportional hazards model were used to assess the VTE risk. RESULTS: The 5-year cumulative risk for VTE was significantly higher in the cervical cancer group than in the control group (3.3% vs 0.3%, p < 0.001). The hazard ratio for VTE was 10.14 times higher in the cervical cancer group than in the controls. The combined presence of more comorbidities was associated with a higher risk for VTE. Furthermore, cervical cancer patients without VTE had a significantly higher survival (75.3% vs 30.3%, p < 0.001). CONCLUSIONS: The cumulative risk of VTE was significantly higher in cervical cancer patients, and these patients also had lower survival rates. Strategies to reduce these risks need to be examined. BioMed Central 2012-06-21 /pmc/articles/PMC3410881/ /pubmed/22721503 http://dx.doi.org/10.1186/1756-0500-5-316 Text en Copyright ©2012 Tsai et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Tsai, Shiang-Jiun Ruan, Ying-Xu Lee, Ching-Chih Lee, Moon-Sing Chiou, Wen-Yen Lin, Hon-Yi Hsu, Feng-Chun Su, Yu-Chieh Hung, Shih-Kai The incidence of venous thromboembolism in cervical cancer: a nationwide population-based study |
title | The incidence of venous thromboembolism in cervical cancer: a nationwide population-based study |
title_full | The incidence of venous thromboembolism in cervical cancer: a nationwide population-based study |
title_fullStr | The incidence of venous thromboembolism in cervical cancer: a nationwide population-based study |
title_full_unstemmed | The incidence of venous thromboembolism in cervical cancer: a nationwide population-based study |
title_short | The incidence of venous thromboembolism in cervical cancer: a nationwide population-based study |
title_sort | incidence of venous thromboembolism in cervical cancer: a nationwide population-based study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410881/ https://www.ncbi.nlm.nih.gov/pubmed/22721503 http://dx.doi.org/10.1186/1756-0500-5-316 |
work_keys_str_mv | AT tsaishiangjiun theincidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT ruanyingxu theincidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT leechingchih theincidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT leemoonsing theincidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT chiouwenyen theincidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT linhonyi theincidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT hsufengchun theincidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT suyuchieh theincidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT hungshihkai theincidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT tsaishiangjiun incidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT ruanyingxu incidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT leechingchih incidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT leemoonsing incidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT chiouwenyen incidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT linhonyi incidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT hsufengchun incidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT suyuchieh incidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy AT hungshihkai incidenceofvenousthromboembolismincervicalcanceranationwidepopulationbasedstudy |