Cargando…

Structural and Biochemical Basis for Development of Influenza Virus Inhibitors Targeting the PA Endonuclease

Emerging influenza viruses are a serious threat to human health because of their pandemic potential. A promising target for the development of novel anti-influenza therapeutics is the PA protein, whose endonuclease activity is essential for viral replication. Translation of viral mRNAs by the host r...

Descripción completa

Detalles Bibliográficos
Autores principales:	DuBois, Rebecca M., Slavish, P. Jake, Baughman, Brandi M., Yun, Mi-Kyung, Bao, Ju, Webby, Richard J., Webb, Thomas R., White, Stephen W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410894/ https://www.ncbi.nlm.nih.gov/pubmed/22876176 http://dx.doi.org/10.1371/journal.ppat.1002830

Ejemplares similares

Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors
por: Jones, Jeremy C., et al.
Publicado: (2018)

Structural insights into the substrate specificity of the endonuclease activity of the influenza virus cap-snatching mechanism
por: Kumar, Gyanendra, et al.
Publicado: (2021)

Author Correction for Jones et al., “Identification of the I38T PA Substitution as a Resistance Marker for Next-Generation Influenza Virus Endonuclease Inhibitors”
por: Jones, Jeremy C., et al.
Publicado: (2018)

N-acylhydrazone inhibitors of influenza virus PA endonuclease with versatile metal binding modes
por: Carcelli, Mauro, et al.
Publicado: (2016)

Functional properties of the novel PA-X endonuclease of human influenza virus
por: Bavagnoli, Laura, et al.
Publicado: (2014)

Drug Repurposing for Influenza Virus Polymerase Acidic (PA) Endonuclease Inhibitor
por: Meng, Xin, et al.
Publicado: (2021)

An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA
por: Zhao, Jianyuan, et al.
Publicado: (2022)

Protein-Structure Assisted Optimization of 4,5-Dihydroxypyrimidine-6-Carboxamide Inhibitors of Influenza Virus Endonuclease
por: Beylkin, Diane, et al.
Publicado: (2017)

Author Correction: An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA
por: Zhao, Jianyuan, et al.
Publicado: (2023)

The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA
por: Bavagnoli, Laura, et al.
Publicado: (2015)

A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase
por: Yuan, Shuofeng, et al.
Publicado: (2016)

Identification of Influenza PA(N) Endonuclease Inhibitors via 3D-QSAR Modeling and Docking-Based Virtual Screening
por: Zhang, Chao, et al.
Publicado: (2021)

Structural Basis for the Propagation of Homing Endonuclease-Associated Inteins
por: Beyer, Hannes M., et al.
Publicado: (2022)

Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors
por: Xing, Weimei, et al.
Publicado: (2017)

A Contributing Role for Anti-Neuraminidase Antibodies on Immunity to Pandemic H1N1 2009 Influenza A Virus
por: Marcelin, Glendie, et al.
Publicado: (2011)

PA-E18G substitution in influenza A virus confers resistance to ZX-7101, a cap-dependent endonuclease inhibitor
por: Luo, Dan, et al.
Publicado: (2023)

Fragment-Based Identification of Influenza Endonuclease Inhibitors
por: Credille, Cy V., et al.
Publicado: (2016)

Structural basis for sequence-dependent DNA cleavage by nonspecific endonucleases
por: Wang, Yi-Ting, et al.
Publicado: (2007)

Correction to Fragment-Based Identification of Influenza Endonuclease Inhibitors
por: Credille, Cy V., et al.
Publicado: (2017)

Multimeric assembly and biochemical characterization of the Trax/Translin endonuclease complex
por: Tian, Yuan, et al.
Publicado: (2011)

Dissecting endonuclease and exonuclease activities in endonuclease V from Thermotoga maritima
por: Mi, Rongjuan, et al.
Publicado: (2011)

Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori
por: Turgimbayeva, Aigerim, et al.
Publicado: (2018)

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
por: Anders, Carolin, et al.
Publicado: (2014)

Acid Stability of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Pathogenicity
por: DuBois, Rebecca M., et al.
Publicado: (2011)

The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE
por: Neubauer, Cajetan, et al.
Publicado: (2009)

The biochemical basis of neuropharmacology
por: Cooper, Jack R., 1924-
Publicado: (1996)

The biochemical basis of neuropharmacology
por: Cooper, Jack R., 1924-

The Biochemical Basis of Neuropharmacology
por: Kopin, Irwin J.
Publicado: (1971)

The Biochemical Basis of Neuropharmacology
por: Ragen, Lisa
Publicado: (1987)

The biochemical basis of disease
por: Barr, Alastair J.
Publicado: (2018)

Global update on the susceptibilities of human influenza viruses to neuraminidase inhibitors and the cap-dependent endonuclease inhibitor baloxavir, 2018–2020
por: Govorkova, Elena A., et al.
Publicado: (2022)

Characterization of the sequence specificity of the R1Bm endonuclease domain by structural and biochemical studies
por: Maita, Nobuo, et al.
Publicado: (2007)

Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors
por: Stokes, Ryjul W., et al.
Publicado: (2022)

A novel compound to overcome influenza drug resistance in endonuclease inhibitors
por: Ren, Yixin, et al.
Publicado: (2023)

Impact of influenza PA-X on host response
por: Hayashi, Tsuyoshi, et al.
Publicado: (2015)

The Biochemical Basis of Pulmonary Function
por: Reynolds, Herbert Y.
Publicado: (1978)

Structural basis of 5′ flap recognition and protein–protein interactions of human flap endonuclease 1
por: Xu, Hong, et al.
Publicado: (2018)

Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein
por: Fernández-García, Yaiza, et al.
Publicado: (2016)

Biochemical characterization and novel inhibitor identification of Mycobacterium tuberculosis Endonuclease VIII 2 (Rv3297)
por: Lata, Kiran, et al.
Publicado: (2017)

Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil
por: Omoto, Shinya, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_vrdp9gusm5vreg28avnijv62b8