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Dissecting and Circumventing the Requirement for RAM in CSL-Dependent Notch Signaling

The Notch signaling pathway is an intercellular communication network vital to metazoan development. Notch activation leads to the nuclear localization of the intracellular portion (NICD) of the Notch receptor. Once in the nucleus, NICD binds the transcription factor CSL through a bivalent interacti...

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Detalles Bibliográficos
Autores principales: Johnson, Scott E., Barrick, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410904/
https://www.ncbi.nlm.nih.gov/pubmed/22876274
http://dx.doi.org/10.1371/journal.pone.0039093

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