SCN5A Mutations in Brugada Syndrome Are Associated with Increased Cardiac Dimensions and Reduced Contractility

BACKGROUND: The cardiac sodium channel (Na(v)1.5) controls cardiac excitability. Accordingly, SCN5A mutations that result in loss-of-function of Na(v)1.5 are associated with various inherited arrhythmia syndromes that revolve around reduced cardiac excitability, most notably Brugada syndrome (BrS)....

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Detalles Bibliográficos
Autores principales: van Hoorn, Frans, Campian, Maria E., Spijkerboer, Anje, Blom, Marieke T., Planken, R. Nils, van Rossum, Albert C., de Bakker, Jacques M T., Wilde, Arthur A M., Groenink, Maarten, Tan, Hanno L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410911/
https://www.ncbi.nlm.nih.gov/pubmed/22876298
http://dx.doi.org/10.1371/journal.pone.0042037

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