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Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria targeted restriction endonuclease

Mitochondrial diseases are frequently caused by heteroplasmic mtDNA mutations. Because these mutations express themselves only at high relative ratios, any approach able to manipulate mtDNA heteroplasmy can potentially be curative. In this study we developed a system to manipulate mtDNA heteroplasmy...

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Detalles Bibliográficos
Autores principales:	Bacman, Sandra R., Williams, Sion L., Duan, Dongsheng, Moraes, Carlos T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410960/ https://www.ncbi.nlm.nih.gov/pubmed/22130448 http://dx.doi.org/10.1038/gt.2011.196

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